Total Tumor Cell Elimination with Minimum Damage to Normal Tissues in Musculoskeletal Sarcomas following Photodynamic Therapy with Acridine Orange
Acridine orange (AO) has unique biological actions enabling tumor visualization (fluorovisualization) and a strong cytocidal effect (photodynamic therapy: AO-PDT) under illumination with blue light. Accordingly, in this study, we attempted to develop a new surgical technique for total tumor cell eli...
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| Veröffentlicht in: | Oncology 2000-01, Vol.59 (2), p.174-180 |
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| container_title | Oncology |
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| creator | Kusuzaki, Katsuyuki Aomori, Katsuhiro Suginoshita, Takehiko Minami, Ginjorou Takeshita, Hideyuki Murata, Hiroaki Hashiguchi, Shin Ashihara, Tsukasa Hirasawa, Yasusuke |
| description | Acridine orange (AO) has unique biological actions enabling tumor visualization (fluorovisualization) and a strong cytocidal effect (photodynamic therapy: AO-PDT) under illumination with blue light. Accordingly, in this study, we attempted to develop a new surgical technique for total tumor cell elimination using these photodynamic reactions with AO in a mouse osteosarcoma model. The results showed that local tumor recurrence was significantly inhibited (23%) in the group treated with curettage under fluorovisualization and AO-PDT, compared to that (80%) in the control group treated with curettage alone under ordinary light. Therefore, we concluded that the combination of curettage under fluorovisualization and AO-PDT may be useful for total tumor cell elimination with minimum damage to normal tissue in musculoskeletal sarcomas. |
| doi_str_mv | 10.1159/000012156 |
| format | Article |
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Accordingly, in this study, we attempted to develop a new surgical technique for total tumor cell elimination using these photodynamic reactions with AO in a mouse osteosarcoma model. The results showed that local tumor recurrence was significantly inhibited (23%) in the group treated with curettage under fluorovisualization and AO-PDT, compared to that (80%) in the control group treated with curettage alone under ordinary light. Therefore, we concluded that the combination of curettage under fluorovisualization and AO-PDT may be useful for total tumor cell elimination with minimum damage to normal tissue in musculoskeletal sarcomas.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000012156</identifier><identifier>PMID: 10971178</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Acridine Orange - therapeutic use ; Animals ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Bone Neoplasms - drug therapy ; Curettage ; Disease Models, Animal ; Laboratory Investigation ; Male ; Medical sciences ; Mice ; Mice, Inbred C3H ; Musculoskeletal Diseases - drug therapy ; Mutagens - therapeutic use ; Osteosarcoma - drug therapy ; Photochemotherapy ; Photoradiation therapy and photosensitizing agent ; Treatment Outcome ; Treatment with physical agents ; Treatment. General aspects ; Tumors</subject><ispartof>Oncology, 2000-01, Vol.59 (2), p.174-180</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel.</rights><rights>Copyright (c) 2000 S. 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Accordingly, in this study, we attempted to develop a new surgical technique for total tumor cell elimination using these photodynamic reactions with AO in a mouse osteosarcoma model. The results showed that local tumor recurrence was significantly inhibited (23%) in the group treated with curettage under fluorovisualization and AO-PDT, compared to that (80%) in the control group treated with curettage alone under ordinary light. Therefore, we concluded that the combination of curettage under fluorovisualization and AO-PDT may be useful for total tumor cell elimination with minimum damage to normal tissue in musculoskeletal sarcomas.</description><subject>Acridine Orange - therapeutic use</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Curettage</subject><subject>Disease Models, Animal</subject><subject>Laboratory Investigation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Musculoskeletal Diseases - drug therapy</subject><subject>Mutagens - therapeutic use</subject><subject>Osteosarcoma - drug therapy</subject><subject>Photochemotherapy</subject><subject>Photoradiation therapy and photosensitizing agent</subject><subject>Treatment Outcome</subject><subject>Treatment with physical agents</subject><subject>Treatment. 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Accordingly, in this study, we attempted to develop a new surgical technique for total tumor cell elimination using these photodynamic reactions with AO in a mouse osteosarcoma model. The results showed that local tumor recurrence was significantly inhibited (23%) in the group treated with curettage under fluorovisualization and AO-PDT, compared to that (80%) in the control group treated with curettage alone under ordinary light. Therefore, we concluded that the combination of curettage under fluorovisualization and AO-PDT may be useful for total tumor cell elimination with minimum damage to normal tissue in musculoskeletal sarcomas.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10971178</pmid><doi>10.1159/000012156</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0030-2414 |
| ispartof | Oncology, 2000-01, Vol.59 (2), p.174-180 |
| issn | 0030-2414 1423-0232 |
| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Acridine Orange - therapeutic use Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Bone Neoplasms - drug therapy Curettage Disease Models, Animal Laboratory Investigation Male Medical sciences Mice Mice, Inbred C3H Musculoskeletal Diseases - drug therapy Mutagens - therapeutic use Osteosarcoma - drug therapy Photochemotherapy Photoradiation therapy and photosensitizing agent Treatment Outcome Treatment with physical agents Treatment. General aspects Tumors |
| title | Total Tumor Cell Elimination with Minimum Damage to Normal Tissues in Musculoskeletal Sarcomas following Photodynamic Therapy with Acridine Orange |
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