RCAS1 Decidual Immunoreactivity during Cesarean Section in Scar Deciduosis: Immune Cell Presence and Activity
Introduction:Scar deciduosis provides a research model that enables us to assess the impact of decidua on the activity and quality of the immune cells infiltrating this scar tissue. This unique model allows us to examine these processes under conditions excluding the impact of placental cells which,...
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| Veröffentlicht in: | Gynecologic and obstetric investigation 2008-01, Vol.65 (3), p.187-194 |
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| creator | Skret-Magierlo, Joanna Wicherek, Lukasz Basta, Pawel Galazka, Krystyna Sikora, Jerzy Wilk, Mariusz Fudali, Ludmiła Skret, Andrzej |
| description | Introduction:Scar deciduosis provides a research model that enables us to assess the impact of decidua on the activity and quality of the immune cells infiltrating this scar tissue. This unique model allows us to examine these processes under conditions excluding the impact of placental cells which, along with decidual cells, control the activity of immune cells under physiological conditions. RCAS1 is a protein responsible for the suppression of the cytotoxic immune response during gestation. The present study evaluates the immunoreactivity level of RCAS1 with respect to immune cell status in the decidua and scar deciduosis. Material and Methods:Immunohistochemical analysis of RCAS1, CD3, CD56, CD25, and CD69 antigen immunoreactivity levels was performed in tissue samples derived from scar deciduosis that developed after a previous cesarean section and were excised during a subsequent cesarean section. The control group consisted of decidua samples derived from cesarean section at term. Results:A statistically significantly higher RCAS1 immunoreactivity level was identified in scar deciduosis tissue samples than in decidua derived from a cesarean section at term. The number of CD56+ cells and immunoreactivity of the CD25 antigen level were observed to be statistically significantly higher in scar deciduosis than in the control group. Conclusion:The presence of an enhanced number of immune cells of higher activity in ectopic decidua during the final step of decidualization seems to be associated with an increase in the immunoreactivity level of RCAS1. |
| doi_str_mv | 10.1159/000111533 |
| format | Article |
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This unique model allows us to examine these processes under conditions excluding the impact of placental cells which, along with decidual cells, control the activity of immune cells under physiological conditions. RCAS1 is a protein responsible for the suppression of the cytotoxic immune response during gestation. The present study evaluates the immunoreactivity level of RCAS1 with respect to immune cell status in the decidua and scar deciduosis. Material and Methods:Immunohistochemical analysis of RCAS1, CD3, CD56, CD25, and CD69 antigen immunoreactivity levels was performed in tissue samples derived from scar deciduosis that developed after a previous cesarean section and were excised during a subsequent cesarean section. The control group consisted of decidua samples derived from cesarean section at term. Results:A statistically significantly higher RCAS1 immunoreactivity level was identified in scar deciduosis tissue samples than in decidua derived from a cesarean section at term. The number of CD56+ cells and immunoreactivity of the CD25 antigen level were observed to be statistically significantly higher in scar deciduosis than in the control group. Conclusion:The presence of an enhanced number of immune cells of higher activity in ectopic decidua during the final step of decidualization seems to be associated with an increase in the immunoreactivity level of RCAS1.</description><identifier>ISSN: 0378-7346</identifier><identifier>EISSN: 1423-002X</identifier><identifier>DOI: 10.1159/000111533</identifier><identifier>PMID: 18032910</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Antigens, Neoplasm - immunology ; Biological and medical sciences ; CD3 Complex - immunology ; CD56 Antigen - immunology ; Cesarean Section ; Cicatrix - immunology ; Decidua - immunology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphocytes - immunology ; Medical sciences ; Original Article ; Pregnancy</subject><ispartof>Gynecologic and obstetric investigation, 2008-01, Vol.65 (3), p.187-194</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>2008 INIST-CNRS</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-c565b871e81aa23f8cd265cf5088cbec472d84f7721ebaaef16f63e7a222ad583</citedby><cites>FETCH-LOGICAL-c392t-c565b871e81aa23f8cd265cf5088cbec472d84f7721ebaaef16f63e7a222ad583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,2425,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20259876$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18032910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skret-Magierlo, Joanna</creatorcontrib><creatorcontrib>Wicherek, Lukasz</creatorcontrib><creatorcontrib>Basta, Pawel</creatorcontrib><creatorcontrib>Galazka, Krystyna</creatorcontrib><creatorcontrib>Sikora, Jerzy</creatorcontrib><creatorcontrib>Wilk, Mariusz</creatorcontrib><creatorcontrib>Fudali, Ludmiła</creatorcontrib><creatorcontrib>Skret, Andrzej</creatorcontrib><title>RCAS1 Decidual Immunoreactivity during Cesarean Section in Scar Deciduosis: Immune Cell Presence and Activity</title><title>Gynecologic and obstetric investigation</title><addtitle>Gynecol Obstet Invest</addtitle><description>Introduction:Scar deciduosis provides a research model that enables us to assess the impact of decidua on the activity and quality of the immune cells infiltrating this scar tissue. This unique model allows us to examine these processes under conditions excluding the impact of placental cells which, along with decidual cells, control the activity of immune cells under physiological conditions. RCAS1 is a protein responsible for the suppression of the cytotoxic immune response during gestation. The present study evaluates the immunoreactivity level of RCAS1 with respect to immune cell status in the decidua and scar deciduosis. Material and Methods:Immunohistochemical analysis of RCAS1, CD3, CD56, CD25, and CD69 antigen immunoreactivity levels was performed in tissue samples derived from scar deciduosis that developed after a previous cesarean section and were excised during a subsequent cesarean section. The control group consisted of decidua samples derived from cesarean section at term. Results:A statistically significantly higher RCAS1 immunoreactivity level was identified in scar deciduosis tissue samples than in decidua derived from a cesarean section at term. The number of CD56+ cells and immunoreactivity of the CD25 antigen level were observed to be statistically significantly higher in scar deciduosis than in the control group. Conclusion:The presence of an enhanced number of immune cells of higher activity in ectopic decidua during the final step of decidualization seems to be associated with an increase in the immunoreactivity level of RCAS1.</description><subject>Adult</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Biological and medical sciences</subject><subject>CD3 Complex - immunology</subject><subject>CD56 Antigen - immunology</subject><subject>Cesarean Section</subject><subject>Cicatrix - immunology</subject><subject>Decidua - immunology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Original Article</subject><subject>Pregnancy</subject><issn>0378-7346</issn><issn>1423-002X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0c1LHTEQAPBQLPVpPfReJBQs9LBtMtlNsr09Xr8EoaUqeFvmZWclupu1yduC_30juyh46SlD8ptJJsPYGyk-SlnVn4QQMgdKvWArWYIqhICrPbYSytjCqFLvs4OUbrKqalu-YvvSCgW1FCs2_N6szyX_Qs63E_b8dBimMEZCt_N__e6et1P04ZpvKGHeDfyc8skYuM-hw7hkjsmnz3MyZdv3_FekRMERx9Dy9VLtNXvZYZ_oaFkP2eW3rxebH8XZz--nm_VZ4VQNu8JVutpaI8lKRFCddS3oynWVsNZtyZUGWlt2xoCkLSJ1UndakUEAwLay6pC9n-vexfHPRGnXDD65_CwMNE6p0XX-LwP6vxBELUqjTYbvnsGbcYohN9EAKKPBqiqjDzNycUwpUtfcRT9gvG-kaB4m1TxOKtvjpeC0Hah9kstoMjhZACaHfRcxOJ8eHQjIwzQPLbyd3S3Ga4pPheZ7_gEmTaLH</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Skret-Magierlo, Joanna</creator><creator>Wicherek, Lukasz</creator><creator>Basta, Pawel</creator><creator>Galazka, Krystyna</creator><creator>Sikora, Jerzy</creator><creator>Wilk, Mariusz</creator><creator>Fudali, Ludmiła</creator><creator>Skret, Andrzej</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>RCAS1 Decidual Immunoreactivity during Cesarean Section in Scar Deciduosis: Immune Cell Presence and Activity</title><author>Skret-Magierlo, Joanna ; Wicherek, Lukasz ; Basta, Pawel ; Galazka, Krystyna ; Sikora, Jerzy ; Wilk, Mariusz ; Fudali, Ludmiła ; Skret, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-c565b871e81aa23f8cd265cf5088cbec472d84f7721ebaaef16f63e7a222ad583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Biological and medical sciences</topic><topic>CD3 Complex - immunology</topic><topic>CD56 Antigen - immunology</topic><topic>Cesarean Section</topic><topic>Cicatrix - immunology</topic><topic>Decidua - immunology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Original Article</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skret-Magierlo, Joanna</creatorcontrib><creatorcontrib>Wicherek, Lukasz</creatorcontrib><creatorcontrib>Basta, Pawel</creatorcontrib><creatorcontrib>Galazka, Krystyna</creatorcontrib><creatorcontrib>Sikora, Jerzy</creatorcontrib><creatorcontrib>Wilk, Mariusz</creatorcontrib><creatorcontrib>Fudali, Ludmiła</creatorcontrib><creatorcontrib>Skret, Andrzej</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic and obstetric investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skret-Magierlo, Joanna</au><au>Wicherek, Lukasz</au><au>Basta, Pawel</au><au>Galazka, Krystyna</au><au>Sikora, Jerzy</au><au>Wilk, Mariusz</au><au>Fudali, Ludmiła</au><au>Skret, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RCAS1 Decidual Immunoreactivity during Cesarean Section in Scar Deciduosis: Immune Cell Presence and Activity</atitle><jtitle>Gynecologic and obstetric investigation</jtitle><addtitle>Gynecol Obstet Invest</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>65</volume><issue>3</issue><spage>187</spage><epage>194</epage><pages>187-194</pages><issn>0378-7346</issn><eissn>1423-002X</eissn><coden>GOBIDS</coden><abstract>Introduction:Scar deciduosis provides a research model that enables us to assess the impact of decidua on the activity and quality of the immune cells infiltrating this scar tissue. This unique model allows us to examine these processes under conditions excluding the impact of placental cells which, along with decidual cells, control the activity of immune cells under physiological conditions. RCAS1 is a protein responsible for the suppression of the cytotoxic immune response during gestation. The present study evaluates the immunoreactivity level of RCAS1 with respect to immune cell status in the decidua and scar deciduosis. Material and Methods:Immunohistochemical analysis of RCAS1, CD3, CD56, CD25, and CD69 antigen immunoreactivity levels was performed in tissue samples derived from scar deciduosis that developed after a previous cesarean section and were excised during a subsequent cesarean section. The control group consisted of decidua samples derived from cesarean section at term. Results:A statistically significantly higher RCAS1 immunoreactivity level was identified in scar deciduosis tissue samples than in decidua derived from a cesarean section at term. The number of CD56+ cells and immunoreactivity of the CD25 antigen level were observed to be statistically significantly higher in scar deciduosis than in the control group. Conclusion:The presence of an enhanced number of immune cells of higher activity in ectopic decidua during the final step of decidualization seems to be associated with an increase in the immunoreactivity level of RCAS1.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>18032910</pmid><doi>10.1159/000111533</doi><tpages>8</tpages></addata></record> |
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| ispartof | Gynecologic and obstetric investigation, 2008-01, Vol.65 (3), p.187-194 |
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| source | MEDLINE; Karger Journals |
| subjects | Adult Antigens, Neoplasm - immunology Biological and medical sciences CD3 Complex - immunology CD56 Antigen - immunology Cesarean Section Cicatrix - immunology Decidua - immunology Female Gynecology. Andrology. Obstetrics Humans Lymphocytes - immunology Medical sciences Original Article Pregnancy |
| title | RCAS1 Decidual Immunoreactivity during Cesarean Section in Scar Deciduosis: Immune Cell Presence and Activity |
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