Bronchoalveolar Lavage plus Surfactant in a Piglet Model of Meconium Aspiration Syndrome
Introduction: Meconium aspiration produces airway obstruction and surfactant inhibition. Bronchoalveolar lavage (BAL) and surfactant replacement have been proposed as treatments for the syndrome. Objective: To evaluate the effect of BAL with normal saline followed by a supplementary dose of surfacta...
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| Veröffentlicht in: | Neonatology (Basel, Switzerland) Switzerland), 2008-01, Vol.93 (3), p.188-192 |
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| creator | Colvero, Mauricio Obal Fiori, Humberto Holmer Fiori, Renato Machado Luz, Jorge Hecker de Paula, Davi Oppermann, Christina Pitrez, Paulo Márcio da Silva, Vinícius Duval Colvero, Aline Pieruccini |
| description | Introduction: Meconium aspiration produces airway obstruction and surfactant inhibition. Bronchoalveolar lavage (BAL) and surfactant replacement have been proposed as treatments for the syndrome. Objective: To evaluate the effect of BAL with normal saline followed by a supplementary dose of surfactant in a piglet model of meconium aspiration syndrome. Methods: 15 newborn piglets were used in the study. The animals were ventilated with fixed settings. After inhalation of 4 ml/kg of diluted meconium, the piglets were randomized into three groups: group I (n = 5) – tracheal aspiration without BAL; group II (n = 5) – BAL with normal saline (15 ml/kg), and group III (n = 5) – BAL with normal saline (15 ml/kg) followed by a supplementary dose of surfactant (Curosurf® 100 mg/kg). Arterial blood gas samples were obtained 30 min and 6 h after the inhalation of meconium. Results: A significant increase of PaO 2 values at 6 h after treatment was only observed in group III (from 51 ± 13 to 189 ± 115 mm Hg; p = 0.04). At this time, PaO 2 in group III was significantly higher compared to group II (189 ± 115 and 37 ± 11 mm Hg, respectively; p = 0.023) and showed a borderline significance when compared to group I (p = 0.066). Conclusion: BAL with normal saline followed by a supplementary dose of surfactant may improve oxygenation in an experimental piglet model of meconium aspiration syndrome. |
| doi_str_mv | 10.1159/000110866 |
| format | Article |
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Bronchoalveolar lavage (BAL) and surfactant replacement have been proposed as treatments for the syndrome. Objective: To evaluate the effect of BAL with normal saline followed by a supplementary dose of surfactant in a piglet model of meconium aspiration syndrome. Methods: 15 newborn piglets were used in the study. The animals were ventilated with fixed settings. After inhalation of 4 ml/kg of diluted meconium, the piglets were randomized into three groups: group I (n = 5) – tracheal aspiration without BAL; group II (n = 5) – BAL with normal saline (15 ml/kg), and group III (n = 5) – BAL with normal saline (15 ml/kg) followed by a supplementary dose of surfactant (Curosurf® 100 mg/kg). Arterial blood gas samples were obtained 30 min and 6 h after the inhalation of meconium. Results: A significant increase of PaO 2 values at 6 h after treatment was only observed in group III (from 51 ± 13 to 189 ± 115 mm Hg; p = 0.04). At this time, PaO 2 in group III was significantly higher compared to group II (189 ± 115 and 37 ± 11 mm Hg, respectively; p = 0.023) and showed a borderline significance when compared to group I (p = 0.066). Conclusion: BAL with normal saline followed by a supplementary dose of surfactant may improve oxygenation in an experimental piglet model of meconium aspiration syndrome.</description><identifier>ISSN: 1661-7800</identifier><identifier>EISSN: 1661-7819</identifier><identifier>DOI: 10.1159/000110866</identifier><identifier>PMID: 17992018</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Animals, Newborn ; Blood Gas Analysis ; Bronchoalveolar Lavage - methods ; Disease Models, Animal ; Histocytochemistry ; Humans ; Infant, Newborn ; Meconium Aspiration Syndrome - pathology ; Meconium Aspiration Syndrome - therapy ; Pulmonary Surfactants - therapeutic use ; Random Allocation ; Short Communication ; Swine</subject><ispartof>Neonatology (Basel, Switzerland), 2008-01, Vol.93 (3), p.188-192</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>Copyright (c) 2007 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-64bd6db91d4a6957400729946769165feda129f09e8e0c71e4b11445f774e2713</citedby><cites>FETCH-LOGICAL-c331t-64bd6db91d4a6957400729946769165feda129f09e8e0c71e4b11445f774e2713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17992018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colvero, Mauricio Obal</creatorcontrib><creatorcontrib>Fiori, Humberto Holmer</creatorcontrib><creatorcontrib>Fiori, Renato Machado</creatorcontrib><creatorcontrib>Luz, Jorge Hecker</creatorcontrib><creatorcontrib>de Paula, Davi</creatorcontrib><creatorcontrib>Oppermann, Christina</creatorcontrib><creatorcontrib>Pitrez, Paulo Márcio</creatorcontrib><creatorcontrib>da Silva, Vinícius Duval</creatorcontrib><creatorcontrib>Colvero, Aline Pieruccini</creatorcontrib><title>Bronchoalveolar Lavage plus Surfactant in a Piglet Model of Meconium Aspiration Syndrome</title><title>Neonatology (Basel, Switzerland)</title><addtitle>Neonatology</addtitle><description>Introduction: Meconium aspiration produces airway obstruction and surfactant inhibition. Bronchoalveolar lavage (BAL) and surfactant replacement have been proposed as treatments for the syndrome. Objective: To evaluate the effect of BAL with normal saline followed by a supplementary dose of surfactant in a piglet model of meconium aspiration syndrome. Methods: 15 newborn piglets were used in the study. The animals were ventilated with fixed settings. After inhalation of 4 ml/kg of diluted meconium, the piglets were randomized into three groups: group I (n = 5) – tracheal aspiration without BAL; group II (n = 5) – BAL with normal saline (15 ml/kg), and group III (n = 5) – BAL with normal saline (15 ml/kg) followed by a supplementary dose of surfactant (Curosurf® 100 mg/kg). Arterial blood gas samples were obtained 30 min and 6 h after the inhalation of meconium. Results: A significant increase of PaO 2 values at 6 h after treatment was only observed in group III (from 51 ± 13 to 189 ± 115 mm Hg; p = 0.04). At this time, PaO 2 in group III was significantly higher compared to group II (189 ± 115 and 37 ± 11 mm Hg, respectively; p = 0.023) and showed a borderline significance when compared to group I (p = 0.066). Conclusion: BAL with normal saline followed by a supplementary dose of surfactant may improve oxygenation in an experimental piglet model of meconium aspiration syndrome.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Blood Gas Analysis</subject><subject>Bronchoalveolar Lavage - methods</subject><subject>Disease Models, Animal</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Meconium Aspiration Syndrome - pathology</subject><subject>Meconium Aspiration Syndrome - therapy</subject><subject>Pulmonary Surfactants - therapeutic use</subject><subject>Random Allocation</subject><subject>Short Communication</subject><subject>Swine</subject><issn>1661-7800</issn><issn>1661-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0MtLw0AQBvBFFFsfB-8iiwfBQ3Vmu4_uUcUXtChUwVvYJpOammTrbiL43xtpqeBp5vCbj-Fj7AjhAlHZSwBAhJHWW6yPWuPAjNBub3aAHtuLcQGglNJil_XQWCsAR332dh18nb57V36RL13gY_fl5sSXZRv5tA25SxtXN7youePPxbykhk98RiX3OZ9Q6uuirfhVXBbBNYWv-fS7zoKv6IDt5K6MdLie--z17vbl5mEwfrp_vLkaD9LhEJuBlrNMZzOLmXTaKiMBjLBWaqMtapVT5lDYHCyNCFKDJGeIUqrcGEnC4HCfna1yl8F_thSbpCpiSmXpavJtTAzIIWitOnj6Dy58G-rut0QIYZSyQnfofIXS4GMMlCfLUFQufCcIyW_Xyabrzp6sA9tZRdmfXJfbgeMV-HBhTuEPrO5_AAgsgD4</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Colvero, Mauricio Obal</creator><creator>Fiori, Humberto Holmer</creator><creator>Fiori, Renato Machado</creator><creator>Luz, Jorge Hecker</creator><creator>de Paula, Davi</creator><creator>Oppermann, Christina</creator><creator>Pitrez, Paulo Márcio</creator><creator>da Silva, Vinícius Duval</creator><creator>Colvero, Aline Pieruccini</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Bronchoalveolar Lavage plus Surfactant in a Piglet Model of Meconium Aspiration Syndrome</title><author>Colvero, Mauricio Obal ; Fiori, Humberto Holmer ; Fiori, Renato Machado ; Luz, Jorge Hecker ; de Paula, Davi ; Oppermann, Christina ; Pitrez, Paulo Márcio ; da Silva, Vinícius Duval ; Colvero, Aline Pieruccini</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-64bd6db91d4a6957400729946769165feda129f09e8e0c71e4b11445f774e2713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Blood Gas Analysis</topic><topic>Bronchoalveolar Lavage - methods</topic><topic>Disease Models, Animal</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Meconium Aspiration Syndrome - pathology</topic><topic>Meconium Aspiration Syndrome - therapy</topic><topic>Pulmonary Surfactants - therapeutic use</topic><topic>Random Allocation</topic><topic>Short Communication</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colvero, Mauricio Obal</creatorcontrib><creatorcontrib>Fiori, Humberto Holmer</creatorcontrib><creatorcontrib>Fiori, Renato Machado</creatorcontrib><creatorcontrib>Luz, Jorge Hecker</creatorcontrib><creatorcontrib>de Paula, Davi</creatorcontrib><creatorcontrib>Oppermann, Christina</creatorcontrib><creatorcontrib>Pitrez, Paulo Márcio</creatorcontrib><creatorcontrib>da Silva, Vinícius Duval</creatorcontrib><creatorcontrib>Colvero, Aline Pieruccini</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neonatology (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colvero, Mauricio Obal</au><au>Fiori, Humberto Holmer</au><au>Fiori, Renato Machado</au><au>Luz, Jorge Hecker</au><au>de Paula, Davi</au><au>Oppermann, Christina</au><au>Pitrez, Paulo Márcio</au><au>da Silva, Vinícius Duval</au><au>Colvero, Aline Pieruccini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchoalveolar Lavage plus Surfactant in a Piglet Model of Meconium Aspiration Syndrome</atitle><jtitle>Neonatology (Basel, Switzerland)</jtitle><addtitle>Neonatology</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>93</volume><issue>3</issue><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>1661-7800</issn><eissn>1661-7819</eissn><abstract>Introduction: Meconium aspiration produces airway obstruction and surfactant inhibition. Bronchoalveolar lavage (BAL) and surfactant replacement have been proposed as treatments for the syndrome. Objective: To evaluate the effect of BAL with normal saline followed by a supplementary dose of surfactant in a piglet model of meconium aspiration syndrome. Methods: 15 newborn piglets were used in the study. The animals were ventilated with fixed settings. After inhalation of 4 ml/kg of diluted meconium, the piglets were randomized into three groups: group I (n = 5) – tracheal aspiration without BAL; group II (n = 5) – BAL with normal saline (15 ml/kg), and group III (n = 5) – BAL with normal saline (15 ml/kg) followed by a supplementary dose of surfactant (Curosurf® 100 mg/kg). Arterial blood gas samples were obtained 30 min and 6 h after the inhalation of meconium. Results: A significant increase of PaO 2 values at 6 h after treatment was only observed in group III (from 51 ± 13 to 189 ± 115 mm Hg; p = 0.04). At this time, PaO 2 in group III was significantly higher compared to group II (189 ± 115 and 37 ± 11 mm Hg, respectively; p = 0.023) and showed a borderline significance when compared to group I (p = 0.066). Conclusion: BAL with normal saline followed by a supplementary dose of surfactant may improve oxygenation in an experimental piglet model of meconium aspiration syndrome.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>17992018</pmid><doi>10.1159/000110866</doi><tpages>5</tpages></addata></record> |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn Blood Gas Analysis Bronchoalveolar Lavage - methods Disease Models, Animal Histocytochemistry Humans Infant, Newborn Meconium Aspiration Syndrome - pathology Meconium Aspiration Syndrome - therapy Pulmonary Surfactants - therapeutic use Random Allocation Short Communication Swine |
| title | Bronchoalveolar Lavage plus Surfactant in a Piglet Model of Meconium Aspiration Syndrome |
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