Role of Epidermal Growth Factor Receptor (EGFR)-Signaling Versus Cellular Acidosis Via Na+/H+ Exchanger1(NHE1)-Inhibition in Troglitazone-Induced Growth Arrest of Breast Cancer-Derived Cells MCF-7

Purpose:We previously showed that troglitazone (TRO) induces a profound cellular acidosis in MCF-7 cells as a result of inhibiting Na + /H + exchanger (NHE)1-mediated acid extrusion and this was associated with a marked reduction in cellular proliferation. The present study focuses on TRO-activated...

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Veröffentlicht in:	Cellular physiology and biochemistry 2007-01, Vol.20 (6), p.751-762
Hauptverfasser:	Friday, Ellen, Oliver III, Robert, Welbourne, Tomas, Turturro, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - enzymology Acidosis - metabolism Breast Neoplasms - enzymology Breast Neoplasms - pathology Cation Transport Proteins - antagonists & inhibitors Cell Line, Tumor Cell Proliferation - drug effects Chromans - pharmacology DNA, Neoplasm - biosynthesis Enzyme Activation - drug effects Epidermal Growth Factor - pharmacology ErbB Receptors - genetics ErbB Receptors - metabolism Female Humans Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Original Paper Phosphoproteins - metabolism Signal Transduction - drug effects Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - antagonists & inhibitors Thiazolidinediones - pharmacology Transcriptional Activation - drug effects Troglitazone
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