Long-Term Re-Infection Rate after Helicobacter pylori Eradication in Bangladeshi Adults
Background and Aim: Bangladesh is a developing country with a very high prevalence of Helicobacter pylori infection, which has been ascribed to overcrowding and poor sanitary conditions. It has generally been accepted that the re-infection rate is higher in countries with a high prevalence of H. pyl...
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| Veröffentlicht in: | Digestion 2007-01, Vol.75 (4), p.173-176 |
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| creator | Ahmad, Mian Mashhud Ahmed, Dewan Saifuddin Rowshon, A.H.M. Dhar, Swapan Chandra Rahman, Motiur Hasan, Mahmud Beglinger, Christoph Gyr, Niklaus Khan, A.K. Azad |
| description | Background and Aim: Bangladesh is a developing country with a very high prevalence of Helicobacter pylori infection, which has been ascribed to overcrowding and poor sanitary conditions. It has generally been accepted that the re-infection rate is higher in countries with a high prevalence of H. pylori infection. Short-term follow-up studies support this assumption but no long-term studies are available to confirm or refute this assertion. The present study was aimed to define the long-term H. pylori re-infection rate (6 years after successful eradication) in duodenal ulcer patients. Methods: In a previous study, 90 patients were successfully eradicated for H. pylori and followed-up for 24 months. 17/90 were found to be re-infected (18% re-infection rate per year in the first 12 months) [Gastroenterology 2001;792–798]. The remaining 73 patients were targeted for long-term follow-up. 26/73 were lost to follow-up; 6 symptomatic patients were tested H. pylori positive in the period between 24 and 60 months post-eradication. The remaining 41 patients were evaluated 72 months after successful eradication. The evaluation included clinical history taking, a 13 C-urea breath test (UBT), and endoscopy. Results: Of the 41 H. pylori-eradicated patients analyzed after 72 months, 16 were H. pylori-positive. If the 6 patients, who were tested positive between 24 and 60 months, are added, the total re-infection cases amount to 22 subjects in the period between 24 and 72 months. Therefore, an overall annual re-infection rate 6 years after eradication of 5.02% can be calculated. Six of the 23 symptomatic patients had duodenal ulcer relapse, 5/6 were H. pylori re-infected and one was H. pylori-negative at 72 months post-treatment. Conclusion: The long-term annual H. pylori re-infection rate in Bangladeshi adults is markedly higher than in Western countries but lower than anticipated. In this study, duodenal ulcer relapse is clearly related to H. pylori re-infection. |
| doi_str_mv | 10.1159/000107046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_107046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69029030</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-f2de1718887d49ca9c5304f48ba29dd921555ab3c5e9f4a36e14bfc6c9c575ac3</originalsourceid><addsrcrecordid>eNqF0cFLwzAUBvAgipvTg3eR4kHwUE3StE2Oc0w3GAhj4rGk6cvM7JqZtIf997bbUPHiKbzwex8kH0KXBN8TEosHjDHBKWbJEeoTRkkoeJIeo357TUPKadRDZ96vulGw6BT1SJq2O5T10dvMVstwAW4dzCGcVhpUbWwVzGUNgdQ1uGACpVE2l6obNtvSOhOMnSyMkjtqquBRVstSFuDfTTAsmrL25-hEy9LDxeEcoNen8WI0CWcvz9PRcBYqRnkdaloASQnnPC2YUFKoOMJMM55LKopCUBLHscwjFYPQTEYJEJZrlagWprFU0QDd7nM3zn424OtsbbyCspQV2MZnicBU4Aj_Cylp_yMhHbz5A1e2cVX7iIyImHAhOG_R3R4pZ713oLONM2vpthnBWddJ9t1Ja68PgU2-huJHHkpowdUefEi3BPcrarf_BRUhjgo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195189988</pqid></control><display><type>article</type><title>Long-Term Re-Infection Rate after Helicobacter pylori Eradication in Bangladeshi Adults</title><source>Karger Journals</source><source>MEDLINE</source><creator>Ahmad, Mian Mashhud ; Ahmed, Dewan Saifuddin ; Rowshon, A.H.M. ; Dhar, Swapan Chandra ; Rahman, Motiur ; Hasan, Mahmud ; Beglinger, Christoph ; Gyr, Niklaus ; Khan, A.K. Azad</creator><creatorcontrib>Ahmad, Mian Mashhud ; Ahmed, Dewan Saifuddin ; Rowshon, A.H.M. ; Dhar, Swapan Chandra ; Rahman, Motiur ; Hasan, Mahmud ; Beglinger, Christoph ; Gyr, Niklaus ; Khan, A.K. Azad</creatorcontrib><description>Background and Aim: Bangladesh is a developing country with a very high prevalence of Helicobacter pylori infection, which has been ascribed to overcrowding and poor sanitary conditions. It has generally been accepted that the re-infection rate is higher in countries with a high prevalence of H. pylori infection. Short-term follow-up studies support this assumption but no long-term studies are available to confirm or refute this assertion. The present study was aimed to define the long-term H. pylori re-infection rate (6 years after successful eradication) in duodenal ulcer patients. Methods: In a previous study, 90 patients were successfully eradicated for H. pylori and followed-up for 24 months. 17/90 were found to be re-infected (18% re-infection rate per year in the first 12 months) [Gastroenterology 2001;792–798]. The remaining 73 patients were targeted for long-term follow-up. 26/73 were lost to follow-up; 6 symptomatic patients were tested H. pylori positive in the period between 24 and 60 months post-eradication. The remaining 41 patients were evaluated 72 months after successful eradication. The evaluation included clinical history taking, a 13 C-urea breath test (UBT), and endoscopy. Results: Of the 41 H. pylori-eradicated patients analyzed after 72 months, 16 were H. pylori-positive. If the 6 patients, who were tested positive between 24 and 60 months, are added, the total re-infection cases amount to 22 subjects in the period between 24 and 72 months. Therefore, an overall annual re-infection rate 6 years after eradication of 5.02% can be calculated. Six of the 23 symptomatic patients had duodenal ulcer relapse, 5/6 were H. pylori re-infected and one was H. pylori-negative at 72 months post-treatment. Conclusion: The long-term annual H. pylori re-infection rate in Bangladeshi adults is markedly higher than in Western countries but lower than anticipated. In this study, duodenal ulcer relapse is clearly related to H. pylori re-infection.</description><identifier>ISSN: 0012-2823</identifier><identifier>EISSN: 1421-9867</identifier><identifier>DOI: 10.1159/000107046</identifier><identifier>PMID: 17700024</identifier><identifier>CODEN: DIGEBW</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Anti-Ulcer Agents - therapeutic use ; Bangladesh - epidemiology ; Breath Tests ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Gastroscopy ; Helicobacter Infections - drug therapy ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Original Paper ; Prevalence ; Recurrence ; Risk Factors</subject><ispartof>Digestion, 2007-01, Vol.75 (4), p.173-176</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>(c) 2007 S. Karger AG, Basel</rights><rights>Copyright (c) 2007 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-f2de1718887d49ca9c5304f48ba29dd921555ab3c5e9f4a36e14bfc6c9c575ac3</citedby><cites>FETCH-LOGICAL-c428t-f2de1718887d49ca9c5304f48ba29dd921555ab3c5e9f4a36e14bfc6c9c575ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17700024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmad, Mian Mashhud</creatorcontrib><creatorcontrib>Ahmed, Dewan Saifuddin</creatorcontrib><creatorcontrib>Rowshon, A.H.M.</creatorcontrib><creatorcontrib>Dhar, Swapan Chandra</creatorcontrib><creatorcontrib>Rahman, Motiur</creatorcontrib><creatorcontrib>Hasan, Mahmud</creatorcontrib><creatorcontrib>Beglinger, Christoph</creatorcontrib><creatorcontrib>Gyr, Niklaus</creatorcontrib><creatorcontrib>Khan, A.K. Azad</creatorcontrib><title>Long-Term Re-Infection Rate after Helicobacter pylori Eradication in Bangladeshi Adults</title><title>Digestion</title><addtitle>Digestion</addtitle><description>Background and Aim: Bangladesh is a developing country with a very high prevalence of Helicobacter pylori infection, which has been ascribed to overcrowding and poor sanitary conditions. It has generally been accepted that the re-infection rate is higher in countries with a high prevalence of H. pylori infection. Short-term follow-up studies support this assumption but no long-term studies are available to confirm or refute this assertion. The present study was aimed to define the long-term H. pylori re-infection rate (6 years after successful eradication) in duodenal ulcer patients. Methods: In a previous study, 90 patients were successfully eradicated for H. pylori and followed-up for 24 months. 17/90 were found to be re-infected (18% re-infection rate per year in the first 12 months) [Gastroenterology 2001;792–798]. The remaining 73 patients were targeted for long-term follow-up. 26/73 were lost to follow-up; 6 symptomatic patients were tested H. pylori positive in the period between 24 and 60 months post-eradication. The remaining 41 patients were evaluated 72 months after successful eradication. The evaluation included clinical history taking, a 13 C-urea breath test (UBT), and endoscopy. Results: Of the 41 H. pylori-eradicated patients analyzed after 72 months, 16 were H. pylori-positive. If the 6 patients, who were tested positive between 24 and 60 months, are added, the total re-infection cases amount to 22 subjects in the period between 24 and 72 months. Therefore, an overall annual re-infection rate 6 years after eradication of 5.02% can be calculated. Six of the 23 symptomatic patients had duodenal ulcer relapse, 5/6 were H. pylori re-infected and one was H. pylori-negative at 72 months post-treatment. Conclusion: The long-term annual H. pylori re-infection rate in Bangladeshi adults is markedly higher than in Western countries but lower than anticipated. In this study, duodenal ulcer relapse is clearly related to H. pylori re-infection.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Bangladesh - epidemiology</subject><subject>Breath Tests</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroscopy</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Prevalence</subject><subject>Recurrence</subject><subject>Risk Factors</subject><issn>0012-2823</issn><issn>1421-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0cFLwzAUBvAgipvTg3eR4kHwUE3StE2Oc0w3GAhj4rGk6cvM7JqZtIf997bbUPHiKbzwex8kH0KXBN8TEosHjDHBKWbJEeoTRkkoeJIeo357TUPKadRDZ96vulGw6BT1SJq2O5T10dvMVstwAW4dzCGcVhpUbWwVzGUNgdQ1uGACpVE2l6obNtvSOhOMnSyMkjtqquBRVstSFuDfTTAsmrL25-hEy9LDxeEcoNen8WI0CWcvz9PRcBYqRnkdaloASQnnPC2YUFKoOMJMM55LKopCUBLHscwjFYPQTEYJEJZrlagWprFU0QDd7nM3zn424OtsbbyCspQV2MZnicBU4Aj_Cylp_yMhHbz5A1e2cVX7iIyImHAhOG_R3R4pZ713oLONM2vpthnBWddJ9t1Ja68PgU2-huJHHkpowdUefEi3BPcrarf_BRUhjgo</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Ahmad, Mian Mashhud</creator><creator>Ahmed, Dewan Saifuddin</creator><creator>Rowshon, A.H.M.</creator><creator>Dhar, Swapan Chandra</creator><creator>Rahman, Motiur</creator><creator>Hasan, Mahmud</creator><creator>Beglinger, Christoph</creator><creator>Gyr, Niklaus</creator><creator>Khan, A.K. 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Azad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Re-Infection Rate after Helicobacter pylori Eradication in Bangladeshi Adults</atitle><jtitle>Digestion</jtitle><addtitle>Digestion</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>75</volume><issue>4</issue><spage>173</spage><epage>176</epage><pages>173-176</pages><issn>0012-2823</issn><eissn>1421-9867</eissn><coden>DIGEBW</coden><abstract>Background and Aim: Bangladesh is a developing country with a very high prevalence of Helicobacter pylori infection, which has been ascribed to overcrowding and poor sanitary conditions. It has generally been accepted that the re-infection rate is higher in countries with a high prevalence of H. pylori infection. Short-term follow-up studies support this assumption but no long-term studies are available to confirm or refute this assertion. The present study was aimed to define the long-term H. pylori re-infection rate (6 years after successful eradication) in duodenal ulcer patients. Methods: In a previous study, 90 patients were successfully eradicated for H. pylori and followed-up for 24 months. 17/90 were found to be re-infected (18% re-infection rate per year in the first 12 months) [Gastroenterology 2001;792–798]. The remaining 73 patients were targeted for long-term follow-up. 26/73 were lost to follow-up; 6 symptomatic patients were tested H. pylori positive in the period between 24 and 60 months post-eradication. The remaining 41 patients were evaluated 72 months after successful eradication. The evaluation included clinical history taking, a 13 C-urea breath test (UBT), and endoscopy. Results: Of the 41 H. pylori-eradicated patients analyzed after 72 months, 16 were H. pylori-positive. If the 6 patients, who were tested positive between 24 and 60 months, are added, the total re-infection cases amount to 22 subjects in the period between 24 and 72 months. Therefore, an overall annual re-infection rate 6 years after eradication of 5.02% can be calculated. Six of the 23 symptomatic patients had duodenal ulcer relapse, 5/6 were H. pylori re-infected and one was H. pylori-negative at 72 months post-treatment. Conclusion: The long-term annual H. pylori re-infection rate in Bangladeshi adults is markedly higher than in Western countries but lower than anticipated. In this study, duodenal ulcer relapse is clearly related to H. pylori re-infection.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>17700024</pmid><doi>10.1159/000107046</doi><tpages>4</tpages></addata></record> |
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| ispartof | Digestion, 2007-01, Vol.75 (4), p.173-176 |
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| subjects | Adult Aged Anti-Bacterial Agents - therapeutic use Anti-Ulcer Agents - therapeutic use Bangladesh - epidemiology Breath Tests Drug Therapy, Combination Female Follow-Up Studies Gastroscopy Helicobacter Infections - drug therapy Helicobacter Infections - epidemiology Helicobacter pylori Humans Longitudinal Studies Male Middle Aged Original Paper Prevalence Recurrence Risk Factors |
| title | Long-Term Re-Infection Rate after Helicobacter pylori Eradication in Bangladeshi Adults |
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