Hyperandrogenism and Adrenocortical Tumors

Androgen-secreting tumors are a rare cause of hyperandrogenism of adrenal origin. Although these tumors are identified in less than 2% of patients, the prevalence of adrenocortical carcinomas is relevant (2/3 of the cases). Those tumors are associated with simultaneous elevation of several androgens...

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1. Verfasser:	Di Dalmazi, Guido
Format:	Buchkapitel
Sprache:	eng
Schlagworte:	Adrenal Cortex Neoplasms - epidemiology Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - pathology Adrenal Cortex Neoplasms - physiopathology Androgens - metabolism Chapter Humans Hyperandrogenism - metabolism
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description	Androgen-secreting tumors are a rare cause of hyperandrogenism of adrenal origin. Although these tumors are identified in less than 2% of patients, the prevalence of adrenocortical carcinomas is relevant (2/3 of the cases). Those tumors are associated with simultaneous elevation of several androgens, mainly androstenedione, DHEAS, and testosterone, in more than half of the patients, as measured either by immunoassay or mass spectrometry. Despite the recent advances on the pathogenesis of adrenocortical tumors, to date no driver molecular event have been identified in those tumors. This chapter provides a comprehensive review of all studies published in the last 20 years on androgen-secreting tumors, with focus on epidemiology, clinical presentation, and hormonal profile.
doi_str_mv	10.1159/000494905
format	Book Chapter
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subjects	Adrenal Cortex Neoplasms - epidemiology Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - pathology Adrenal Cortex Neoplasms - physiopathology Androgens - metabolism Chapter Humans Hyperandrogenism - metabolism
title	Hyperandrogenism and Adrenocortical Tumors
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