Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease
Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the...
Gespeichert in:
| Veröffentlicht in: | Nestle Nutrition Institute workshop series 2014-01, Vol.79, p.131-140 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 140 |
|---|---|
| container_issue | |
| container_start_page | 131 |
| container_title | Nestle Nutrition Institute workshop series |
| container_volume | 79 |
| creator | Levine, Arie |
| description | Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the resident flora, diminish or damage the mucous layer, increase intestinal permeability or increase the ability of pathobionts to adhere to epithelial cells or translocate across the epithelial barrier. This chapter reviews the possible effects of different dietary components present in the Western diet to affect bacterial clearance mechanisms, and offers a hypothetical model for an acquired bacterial clearance defect in CD. |
| doi_str_mv | 10.1159/000360719 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_karge</sourceid><recordid>TN_cdi_karger_ebooksseries_360719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>25227301</sourcerecordid><originalsourceid>FETCH-LOGICAL-k237t-6407cebf8c18de2767de7dc32878357291f8fbea5486209f6aa9b46d424db4093</originalsourceid><addsrcrecordid>eNpNkDtPwzAcxM1LtCod-ALITEwBvx9sKBSoVAEDzJGT_NOGpjGyHQTfnkoFxHTDnX66O4ROKbmkVNorQghXRFO7h6ZWG86pIUxpwvbRmColMkalPPjvKasO_zyhR2ga49sWQ5mRlutjNGKSMc0JHaP57LPqhth-AJ71CYLr8OOQQpta31_jvBsg4uRxWgF-dmnll9BDbCP2Dc6DX_UXEd-2EVyEE3TUuC7C9Ecn6PVu9pI_ZIun-3l-s8jWjOuUKUF0BWVjKmpqYFrpGnRdcWa2_aVmljamKcFJYRQjtlHO2VKoWjBRl4JYPkFnO-77UG6gLt5Du3Hhq_jdtA2c7wJrF5YQCii9X8cIoYVY7K7k3-AUXbM</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease</title><source>MEDLINE</source><source>eBooks on EBSCOhost</source><source>Karger eBooks Collection</source><creator>Levine, Arie</creator><contributor>Ruemmele FM ; Wu GD ; Lewis JD</contributor><creatorcontrib>Levine, Arie ; Ruemmele FM ; Wu GD ; Lewis JD</creatorcontrib><description>Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the resident flora, diminish or damage the mucous layer, increase intestinal permeability or increase the ability of pathobionts to adhere to epithelial cells or translocate across the epithelial barrier. This chapter reviews the possible effects of different dietary components present in the Western diet to affect bacterial clearance mechanisms, and offers a hypothetical model for an acquired bacterial clearance defect in CD.</description><identifier>ISSN: 1664-2147</identifier><identifier>ISBN: 9783318026696</identifier><identifier>ISBN: 3318026697</identifier><identifier>EISSN: 1664-2155</identifier><identifier>EISBN: 9783318026702</identifier><identifier>EISBN: 3318026700</identifier><identifier>DOI: 10.1159/000360719</identifier><identifier>PMID: 25227301</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Animals ; Chapter ; Child ; Crohn Disease - etiology ; Crohn Disease - pathology ; Crohn Disease - therapy ; Diet, Western - adverse effects ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Dietary Fiber - administration & dosage ; Dietary Proteins - administration & dosage ; Disease Models, Animal ; Enteral Nutrition - methods ; Fruit ; Humans ; Intestines - metabolism ; Intestines - microbiology ; Microbiota ; Vegetables</subject><ispartof>Nestle Nutrition Institute workshop series, 2014-01, Vol.79, p.131-140</ispartof><rights>2014 Nestec Ltd., Vevey/S. Karger AG, Basel</rights><rights>2014 Nestec Ltd., Vevey/S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>779,780,784,793,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25227301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ruemmele FM</contributor><contributor>Wu GD</contributor><contributor>Lewis JD</contributor><creatorcontrib>Levine, Arie</creatorcontrib><title>Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease</title><title>Nestle Nutrition Institute workshop series</title><addtitle>Nestle Nutr Inst Workshop Ser</addtitle><description>Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the resident flora, diminish or damage the mucous layer, increase intestinal permeability or increase the ability of pathobionts to adhere to epithelial cells or translocate across the epithelial barrier. This chapter reviews the possible effects of different dietary components present in the Western diet to affect bacterial clearance mechanisms, and offers a hypothetical model for an acquired bacterial clearance defect in CD.</description><subject>Adult</subject><subject>Animals</subject><subject>Chapter</subject><subject>Child</subject><subject>Crohn Disease - etiology</subject><subject>Crohn Disease - pathology</subject><subject>Crohn Disease - therapy</subject><subject>Diet, Western - adverse effects</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Enteral Nutrition - methods</subject><subject>Fruit</subject><subject>Humans</subject><subject>Intestines - metabolism</subject><subject>Intestines - microbiology</subject><subject>Microbiota</subject><subject>Vegetables</subject><issn>1664-2147</issn><issn>1664-2155</issn><isbn>9783318026696</isbn><isbn>3318026697</isbn><isbn>9783318026702</isbn><isbn>3318026700</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAcxM1LtCod-ALITEwBvx9sKBSoVAEDzJGT_NOGpjGyHQTfnkoFxHTDnX66O4ROKbmkVNorQghXRFO7h6ZWG86pIUxpwvbRmColMkalPPjvKasO_zyhR2ga49sWQ5mRlutjNGKSMc0JHaP57LPqhth-AJ71CYLr8OOQQpta31_jvBsg4uRxWgF-dmnll9BDbCP2Dc6DX_UXEd-2EVyEE3TUuC7C9Ecn6PVu9pI_ZIun-3l-s8jWjOuUKUF0BWVjKmpqYFrpGnRdcWa2_aVmljamKcFJYRQjtlHO2VKoWjBRl4JYPkFnO-77UG6gLt5Du3Hhq_jdtA2c7wJrF5YQCii9X8cIoYVY7K7k3-AUXbM</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Levine, Arie</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20140101</creationdate><title>Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease</title><author>Levine, Arie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k237t-6407cebf8c18de2767de7dc32878357291f8fbea5486209f6aa9b46d424db4093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Chapter</topic><topic>Child</topic><topic>Crohn Disease - etiology</topic><topic>Crohn Disease - pathology</topic><topic>Crohn Disease - therapy</topic><topic>Diet, Western - adverse effects</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Enteral Nutrition - methods</topic><topic>Fruit</topic><topic>Humans</topic><topic>Intestines - metabolism</topic><topic>Intestines - microbiology</topic><topic>Microbiota</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Arie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nestle Nutrition Institute workshop series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Arie</au><au>Ruemmele FM</au><au>Wu GD</au><au>Lewis JD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease</atitle><jtitle>Nestle Nutrition Institute workshop series</jtitle><addtitle>Nestle Nutr Inst Workshop Ser</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>79</volume><spage>131</spage><epage>140</epage><pages>131-140</pages><issn>1664-2147</issn><eissn>1664-2155</eissn><isbn>9783318026696</isbn><isbn>3318026697</isbn><eisbn>9783318026702</eisbn><eisbn>3318026700</eisbn><abstract>Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the resident flora, diminish or damage the mucous layer, increase intestinal permeability or increase the ability of pathobionts to adhere to epithelial cells or translocate across the epithelial barrier. This chapter reviews the possible effects of different dietary components present in the Western diet to affect bacterial clearance mechanisms, and offers a hypothetical model for an acquired bacterial clearance defect in CD.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25227301</pmid><doi>10.1159/000360719</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1664-2147 |
| ispartof | Nestle Nutrition Institute workshop series, 2014-01, Vol.79, p.131-140 |
| issn | 1664-2147 1664-2155 |
| language | eng |
| recordid | cdi_karger_ebooksseries_360719 |
| source | MEDLINE; eBooks on EBSCOhost; Karger eBooks Collection |
| subjects | Adult Animals Chapter Child Crohn Disease - etiology Crohn Disease - pathology Crohn Disease - therapy Diet, Western - adverse effects Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Dietary Fiber - administration & dosage Dietary Proteins - administration & dosage Disease Models, Animal Enteral Nutrition - methods Fruit Humans Intestines - metabolism Intestines - microbiology Microbiota Vegetables |
| title | Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A36%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exclusive%20Enteral%20Nutrition:%20Clues%20to%20the%20Pathogenesis%20of%20Crohn's%20Disease&rft.jtitle=Nestle%20Nutrition%20Institute%20workshop%20series&rft.au=Levine,%20Arie&rft.date=2014-01-01&rft.volume=79&rft.spage=131&rft.epage=140&rft.pages=131-140&rft.issn=1664-2147&rft.eissn=1664-2155&rft.isbn=9783318026696&rft.isbn_list=3318026697&rft_id=info:doi/10.1159/000360719&rft_dat=%3Cpubmed_karge%3E25227301%3C/pubmed_karge%3E%3Curl%3E%3C/url%3E&rft.eisbn=9783318026702&rft.eisbn_list=3318026700&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/25227301&rfr_iscdi=true |