Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy represents the major complication in retinal detachment surgery andoccurs in about 5–15% of cases resulting in a significant loss of vision despite multiple surgical procedures. Although successful anatomical reattachment is usually achieved, the reduction in central...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buchkapitel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 55 |
|---|---|
| container_issue | |
| container_start_page | 46 |
| container_title | |
| container_volume | 44 |
| creator | Eibl, Kirsten H. Fisher, Steven K. Lewis, Geoffrey P. |
| description | Proliferative vitreoretinopathy represents the major complication in retinal detachment surgery andoccurs in about 5–15% of cases resulting in a significant loss of vision despite multiple surgical procedures. Although successful anatomical reattachment is usually achieved, the reduction in central vision often remains permanent due to the intraretinal changes induced by retinal detachment and the subsequent proliferative response within the retina. Retinal Müller glial cells play a pivotal role in this process together with retinal pigment epithelial cells which are dispersed in the vitreous and stimulated by growth factors and serum in the vitreous after the breakdown of the blood-retinal barrier. |
| doi_str_mv | 10.1159/000223945 |
| format | Book Chapter |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_ebooksseries_223945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733220868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c276t-ac6b49711aee07dcef4f71337f56e5e03c7aacee96d2e5c960ab2441c23a43f33</originalsourceid><addsrcrecordid>eNpNkUtLAzEUheMLW2sX_gGJK1ejeadxV4ovEHWh4m7IpHec2OlkTKZK_70DreDicuHcj8PhXIROKLmgVJpLQghj3Ai5g474hEhpCCfvu2hIlWIZ04bsobHRk-2NGb2PhoRJknEt6QCNU_rsPYgUQjJ1iAbUCCOUZEME03qxrtsqpH5cFWrfQLrCU_wIP3jatjFYV-Eu4Pum8oXv8AzqGj_HHiwh2s6HBvvmv_AN-M13EUKEzjehtV21PkYHpa0TjLd7hF5vrl9md9nD0-39bPqQOaZVl1mnCmE0pRaA6LmDUpSacq5LqUAC4U5b6wCMmjOQzihiCyYEdYxbwUvOR-h849vn_lpB6vKlT65PbBsIq5RrzhkjEzXpydMtuSqWMM_b6Jc2rvO_ZnrgbAMsbPyAmEMRwiIliB5SvvkG_wWAuXck</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>book_chapter</recordtype><pqid>733220868</pqid></control><display><type>book_chapter</type><title>Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy</title><source>Karger eBooks Collection Archiv (DFG Nationallizenzen)</source><source>MEDLINE</source><source>Karger Book Series</source><creator>Eibl, Kirsten H. ; Fisher, Steven K. ; Lewis, Geoffrey P.</creator><contributor>Gandorfer A</contributor><creatorcontrib>Eibl, Kirsten H. ; Fisher, Steven K. ; Lewis, Geoffrey P. ; Gandorfer A</creatorcontrib><description>Proliferative vitreoretinopathy represents the major complication in retinal detachment surgery andoccurs in about 5–15% of cases resulting in a significant loss of vision despite multiple surgical procedures. Although successful anatomical reattachment is usually achieved, the reduction in central vision often remains permanent due to the intraretinal changes induced by retinal detachment and the subsequent proliferative response within the retina. Retinal Müller glial cells play a pivotal role in this process together with retinal pigment epithelial cells which are dispersed in the vitreous and stimulated by growth factors and serum in the vitreous after the breakdown of the blood-retinal barrier.</description><identifier>ISSN: 0250-3751</identifier><identifier>ISBN: 9783805590297</identifier><identifier>ISBN: 3805590296</identifier><identifier>EISSN: 1662-2790</identifier><identifier>EISBN: 380559030X</identifier><identifier>EISBN: 9783805590303</identifier><identifier>DOI: 10.1159/000223945</identifier><identifier>PMID: 19494652</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Cell Proliferation - drug effects ; Chapter ; Humans ; Injections ; Phosphorylcholine - administration & dosage ; Phosphorylcholine - analogs & derivatives ; Retina - drug effects ; Retina - pathology ; Treatment Outcome ; Vitreoretinopathy, Proliferative - drug therapy ; Vitreoretinopathy, Proliferative - metabolism ; Vitreoretinopathy, Proliferative - pathology ; Vitreous Body</subject><ispartof>Developments in ophthalmology, 2009, Vol.44, p.46-55</ispartof><rights>2009 S. Karger AG, Basel</rights><rights>Copyright 2009 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c276t-ac6b49711aee07dcef4f71337f56e5e03c7aacee96d2e5c960ab2441c23a43f33</citedby><relation>Pharmacology and Vitreoretinal Surgery</relation></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>779,780,784,793,26081,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19494652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gandorfer A</contributor><creatorcontrib>Eibl, Kirsten H.</creatorcontrib><creatorcontrib>Fisher, Steven K.</creatorcontrib><creatorcontrib>Lewis, Geoffrey P.</creatorcontrib><title>Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy</title><title>Developments in ophthalmology</title><addtitle>Dev Ophthalmol</addtitle><description>Proliferative vitreoretinopathy represents the major complication in retinal detachment surgery andoccurs in about 5–15% of cases resulting in a significant loss of vision despite multiple surgical procedures. Although successful anatomical reattachment is usually achieved, the reduction in central vision often remains permanent due to the intraretinal changes induced by retinal detachment and the subsequent proliferative response within the retina. Retinal Müller glial cells play a pivotal role in this process together with retinal pigment epithelial cells which are dispersed in the vitreous and stimulated by growth factors and serum in the vitreous after the breakdown of the blood-retinal barrier.</description><subject>Animals</subject><subject>Cell Proliferation - drug effects</subject><subject>Chapter</subject><subject>Humans</subject><subject>Injections</subject><subject>Phosphorylcholine - administration & dosage</subject><subject>Phosphorylcholine - analogs & derivatives</subject><subject>Retina - drug effects</subject><subject>Retina - pathology</subject><subject>Treatment Outcome</subject><subject>Vitreoretinopathy, Proliferative - drug therapy</subject><subject>Vitreoretinopathy, Proliferative - metabolism</subject><subject>Vitreoretinopathy, Proliferative - pathology</subject><subject>Vitreous Body</subject><issn>0250-3751</issn><issn>1662-2790</issn><isbn>9783805590297</isbn><isbn>3805590296</isbn><isbn>380559030X</isbn><isbn>9783805590303</isbn><fulltext>true</fulltext><rsrctype>book_chapter</rsrctype><creationdate>2009</creationdate><recordtype>book_chapter</recordtype><sourceid>EIF</sourceid><recordid>eNpNkUtLAzEUheMLW2sX_gGJK1ejeadxV4ovEHWh4m7IpHec2OlkTKZK_70DreDicuHcj8PhXIROKLmgVJpLQghj3Ai5g474hEhpCCfvu2hIlWIZ04bsobHRk-2NGb2PhoRJknEt6QCNU_rsPYgUQjJ1iAbUCCOUZEME03qxrtsqpH5cFWrfQLrCU_wIP3jatjFYV-Eu4Pum8oXv8AzqGj_HHiwh2s6HBvvmv_AN-M13EUKEzjehtV21PkYHpa0TjLd7hF5vrl9md9nD0-39bPqQOaZVl1mnCmE0pRaA6LmDUpSacq5LqUAC4U5b6wCMmjOQzihiCyYEdYxbwUvOR-h849vn_lpB6vKlT65PbBsIq5RrzhkjEzXpydMtuSqWMM_b6Jc2rvO_ZnrgbAMsbPyAmEMRwiIliB5SvvkG_wWAuXck</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Eibl, Kirsten H.</creator><creator>Fisher, Steven K.</creator><creator>Lewis, Geoffrey P.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy</title><author>Eibl, Kirsten H. ; Fisher, Steven K. ; Lewis, Geoffrey P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-ac6b49711aee07dcef4f71337f56e5e03c7aacee96d2e5c960ab2441c23a43f33</frbrgroupid><rsrctype>book_chapters</rsrctype><prefilter>book_chapters</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Cell Proliferation - drug effects</topic><topic>Chapter</topic><topic>Humans</topic><topic>Injections</topic><topic>Phosphorylcholine - administration & dosage</topic><topic>Phosphorylcholine - analogs & derivatives</topic><topic>Retina - drug effects</topic><topic>Retina - pathology</topic><topic>Treatment Outcome</topic><topic>Vitreoretinopathy, Proliferative - drug therapy</topic><topic>Vitreoretinopathy, Proliferative - metabolism</topic><topic>Vitreoretinopathy, Proliferative - pathology</topic><topic>Vitreous Body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eibl, Kirsten H.</creatorcontrib><creatorcontrib>Fisher, Steven K.</creatorcontrib><creatorcontrib>Lewis, Geoffrey P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eibl, Kirsten H.</au><au>Fisher, Steven K.</au><au>Lewis, Geoffrey P.</au><au>Gandorfer A</au><format>book</format><genre>bookitem</genre><ristype>CHAP</ristype><atitle>Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy</atitle><btitle>Developments in ophthalmology</btitle><addtitle>Dev Ophthalmol</addtitle><seriestitle>Pharmacology and Vitreoretinal Surgery</seriestitle><date>2009-01-01</date><risdate>2009</risdate><volume>44</volume><spage>46</spage><epage>55</epage><pages>46-55</pages><issn>0250-3751</issn><eissn>1662-2790</eissn><isbn>9783805590297</isbn><isbn>3805590296</isbn><eisbn>380559030X</eisbn><eisbn>9783805590303</eisbn><abstract>Proliferative vitreoretinopathy represents the major complication in retinal detachment surgery andoccurs in about 5–15% of cases resulting in a significant loss of vision despite multiple surgical procedures. Although successful anatomical reattachment is usually achieved, the reduction in central vision often remains permanent due to the intraretinal changes induced by retinal detachment and the subsequent proliferative response within the retina. Retinal Müller glial cells play a pivotal role in this process together with retinal pigment epithelial cells which are dispersed in the vitreous and stimulated by growth factors and serum in the vitreous after the breakdown of the blood-retinal barrier.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>19494652</pmid><doi>10.1159/000223945</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-3751 |
| ispartof | Developments in ophthalmology, 2009, Vol.44, p.46-55 |
| issn | 0250-3751 1662-2790 |
| language | eng |
| recordid | cdi_karger_ebooksseries_223945 |
| source | Karger eBooks Collection Archiv (DFG Nationallizenzen); MEDLINE; Karger Book Series |
| subjects | Animals Cell Proliferation - drug effects Chapter Humans Injections Phosphorylcholine - administration & dosage Phosphorylcholine - analogs & derivatives Retina - drug effects Retina - pathology Treatment Outcome Vitreoretinopathy, Proliferative - drug therapy Vitreoretinopathy, Proliferative - metabolism Vitreoretinopathy, Proliferative - pathology Vitreous Body |
| title | Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T10%3A30%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.atitle=Alkylphosphocholines:%20A%20New%20Approach%20to%20Inhibit%20Cell%20Proliferation%20in%20Proliferative%20Vitreoretinopathy&rft.btitle=Developments%20in%20ophthalmology&rft.au=Eibl,%20Kirsten%20H.&rft.date=2009-01-01&rft.volume=44&rft.spage=46&rft.epage=55&rft.pages=46-55&rft.issn=0250-3751&rft.eissn=1662-2790&rft.isbn=9783805590297&rft.isbn_list=3805590296&rft_id=info:doi/10.1159/000223945&rft_dat=%3Cproquest_karge%3E733220868%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&rft.eisbn=380559030X&rft.eisbn_list=9783805590303&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733220868&rft_id=info:pmid/19494652&rfr_iscdi=true |