The Molecular Basis of Costello Syndrome

Costello syndrome is a rare tumor predisposition syndrome with a distinctive phenotype overlapping with Noonan and cardio-facio-cutaneous syndromes. Based on this information its genetic cause was identified as heterozygous HRAS mutations. HRAS is a well-known oncogene, and aberrant activation of th...

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Bibliographische Detailangaben

Hauptverfasser:	Sol-Church, K., Gripp, K.W.
Format:	Buchkapitel
Sprache:	eng
Schlagworte:	Chapter
Online-Zugang:	Volltext
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