Self-Association and Base Pairing of Guanosine, Cytidine, Adenosine, and Uridine in Dimethyl Sulfoxide Solution Measured by15N Nuclear Magnetic Resonance Spectroscopy

Self-Association and Base Pairing of Guanosine, Cytidine, Adenosine, and Uridine in Dimethyl Sulfoxide Solution Measured by15N Nuclear Magnetic Resonance Spectroscopy

The self-association of guanosine, cytidine, and adenosine and base pairing between guanosine, cytidine, adenosine, and uridine in dimethyl sulfoxide have been investigated by the variation of their15N NMR chemical shifts with concentration and temperature. Guanosine, cytidine, and adenosine all sho...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1980-10, Vol.77 (10), p.5580-5582
Hauptverfasser: Dyllick-Brenzinger, Christina, Sullivan, Glenn R., Pang, Patty P., Roberts, John D.
Format: Artikel
Sprache:eng
Schlagworte:
Addiction
Chemical equilibrium
Chemical mixtures
Dimers
Hydrogen
Hydrogen bonds
Nitrogen
Nucleosides
Sulfoxides
Temperature dependence
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Zusammenfassung:The self-association of guanosine, cytidine, and adenosine and base pairing between guanosine, cytidine, adenosine, and uridine in dimethyl sulfoxide have been investigated by the variation of their15N NMR chemical shifts with concentration and temperature. Guanosine, cytidine, and adenosine all showed evidence of self-association by hydrogen bonding. In guanosine/cytidine mixtures, a hydrogen-bonded dimer is formed; however, no base pairing could be detected with adenosine/cytidine or adenosine/uridine mixtures.
ISSN:0027-8424
1091-6490