Nerve Growth Factor: Acceleration of the Rate of Wound Healing in Mice
Earlier studies have shown that removal of the submandibular glands of mice retards the rate of contraction of experimentally induced wounds and that communal licking of wounds accelerates contraction in intact animals [Hutson, J. M., Niall, M., Evans, D. & Fowler, R. (1979) Nature (London) 279,...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1980-07, Vol.77 (7), p.4379-4381 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Arthur K. C. Li Koroly, Mary J. Schattenkerk, Marinus E. Malt, Ronald A. Young, Michael |
| description | Earlier studies have shown that removal of the submandibular glands of mice retards the rate of contraction of experimentally induced wounds and that communal licking of wounds accelerates contraction in intact animals [Hutson, J. M., Niall, M., Evans, D. & Fowler, R. (1979) Nature (London) 279, 793-795]. In the light of the observation that nerve growth factor (NGF) is secreted in high concentrations in mouse saliva, we have studied the effect of topically applied high molecular weight nerve growth factor (HMW-NGF) upon the rate of wound contraction in sialoadenectomized animals. Results show that HMW-NGF significantly accelerates the rate of wound contraction and that this phenomenon is probably dependent upon the enzymic activity of the protein. Neither diisopropyl fluorophosphate-inactivated NGF nor 2.5S NGF [isolated according to Bocchini, V. & Angeletti, P. U. (1969) Proc. Natl. Acad. Sci. USA 64, 787-794] displays this biological activity. Thus, it may be that one of the physiological roles of NGF in saliva is to promote wound healing by the licking process. |
| doi_str_mv | 10.1073/pnas.77.7.4379 |
| format | Article |
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C. Li ; Koroly, Mary J. ; Schattenkerk, Marinus E. ; Malt, Ronald A. ; Young, Michael</creator><creatorcontrib>Arthur K. C. Li ; Koroly, Mary J. ; Schattenkerk, Marinus E. ; Malt, Ronald A. ; Young, Michael</creatorcontrib><description>Earlier studies have shown that removal of the submandibular glands of mice retards the rate of contraction of experimentally induced wounds and that communal licking of wounds accelerates contraction in intact animals [Hutson, J. M., Niall, M., Evans, D. & Fowler, R. (1979) Nature (London) 279, 793-795]. In the light of the observation that nerve growth factor (NGF) is secreted in high concentrations in mouse saliva, we have studied the effect of topically applied high molecular weight nerve growth factor (HMW-NGF) upon the rate of wound contraction in sialoadenectomized animals. Results show that HMW-NGF significantly accelerates the rate of wound contraction and that this phenomenon is probably dependent upon the enzymic activity of the protein. Neither diisopropyl fluorophosphate-inactivated NGF nor 2.5S NGF [isolated according to Bocchini, V. & Angeletti, P. U. (1969) Proc. Natl. Acad. Sci. USA 64, 787-794] displays this biological activity. Thus, it may be that one of the physiological roles of NGF in saliva is to promote wound healing by the licking process.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.77.7.4379</identifier><identifier>PMID: 6933491</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biochemistry ; Esters ; Male ; Mice ; Molecular weight ; Nerve Growth Factors - pharmacology ; Nerves ; Saliva ; Saliva - physiology ; Salivary glands ; Stimulation, Chemical ; Structure-Activity Relationship ; Submandibular Gland - physiology ; Wound healing ; Wound Healing - drug effects ; Wounds ; Zymogens</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1980-07, Vol.77 (7), p.4379-4381</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-411e27529d9897d64d93d85f99b2fc2024bc4c28e8c8525277145849b3b6fe273</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/77/7.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/9104$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/9104$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6933491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arthur K. C. Li</creatorcontrib><creatorcontrib>Koroly, Mary J.</creatorcontrib><creatorcontrib>Schattenkerk, Marinus E.</creatorcontrib><creatorcontrib>Malt, Ronald A.</creatorcontrib><creatorcontrib>Young, Michael</creatorcontrib><title>Nerve Growth Factor: Acceleration of the Rate of Wound Healing in Mice</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Earlier studies have shown that removal of the submandibular glands of mice retards the rate of contraction of experimentally induced wounds and that communal licking of wounds accelerates contraction in intact animals [Hutson, J. M., Niall, M., Evans, D. & Fowler, R. (1979) Nature (London) 279, 793-795]. In the light of the observation that nerve growth factor (NGF) is secreted in high concentrations in mouse saliva, we have studied the effect of topically applied high molecular weight nerve growth factor (HMW-NGF) upon the rate of wound contraction in sialoadenectomized animals. Results show that HMW-NGF significantly accelerates the rate of wound contraction and that this phenomenon is probably dependent upon the enzymic activity of the protein. Neither diisopropyl fluorophosphate-inactivated NGF nor 2.5S NGF [isolated according to Bocchini, V. & Angeletti, P. U. (1969) Proc. Natl. Acad. Sci. USA 64, 787-794] displays this biological activity. Thus, it may be that one of the physiological roles of NGF in saliva is to promote wound healing by the licking process.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Esters</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular weight</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Nerves</subject><subject>Saliva</subject><subject>Saliva - physiology</subject><subject>Salivary glands</subject><subject>Stimulation, Chemical</subject><subject>Structure-Activity Relationship</subject><subject>Submandibular Gland - physiology</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wounds</subject><subject>Zymogens</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9r2zAYhsVo6dJ218EOA516s6tfjqRBD6E0TSHbYHTsKGT5c-PiWJkkt9t_X5ukIb30JMH7PJK-Vwh9piSnRPLLTWdjLmUuc8Gl_oAmlGiaTYUmR2hCCJOZEkx8RKcxPhJCdKHICTqZas6FphM0_wHhCfBt8M9phefWJR--4Zlz0EKwqfEd9jVOK8C_bIJx_8f3XYUXYNume8BNh783Ds7RcW3bCJ926xn6Pb-5v15ky5-3d9ezZeYKRlMmKAUmC6YrrbSspqLSvFJFrXXJascIE6UTjilQThWsYFJSUSihS15O68HkZ-hqe-6mL9dQOehSsK3ZhGZtw3_jbWPeJl2zMg_-yQzTKq4G_2LnB_-3h5jMuonDrK3twPfRyIIzrRkbwHwLuuBjDFDv76DEjMWbsXgjpZFmLH4Qvh6-bI_vmj7IR-81PfQv3stN3bdtgn9pAL9swcc4_NWe1JQI_gIMoZ5v</recordid><startdate>19800701</startdate><enddate>19800701</enddate><creator>Arthur K. C. Li</creator><creator>Koroly, Mary J.</creator><creator>Schattenkerk, Marinus E.</creator><creator>Malt, Ronald A.</creator><creator>Young, Michael</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19800701</creationdate><title>Nerve Growth Factor: Acceleration of the Rate of Wound Healing in Mice</title><author>Arthur K. C. Li ; Koroly, Mary J. ; Schattenkerk, Marinus E. ; Malt, Ronald A. ; Young, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-411e27529d9897d64d93d85f99b2fc2024bc4c28e8c8525277145849b3b6fe273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Esters</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular weight</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>Nerves</topic><topic>Saliva</topic><topic>Saliva - physiology</topic><topic>Salivary glands</topic><topic>Stimulation, Chemical</topic><topic>Structure-Activity Relationship</topic><topic>Submandibular Gland - physiology</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wounds</topic><topic>Zymogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arthur K. C. Li</creatorcontrib><creatorcontrib>Koroly, Mary J.</creatorcontrib><creatorcontrib>Schattenkerk, Marinus E.</creatorcontrib><creatorcontrib>Malt, Ronald A.</creatorcontrib><creatorcontrib>Young, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arthur K. C. Li</au><au>Koroly, Mary J.</au><au>Schattenkerk, Marinus E.</au><au>Malt, Ronald A.</au><au>Young, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nerve Growth Factor: Acceleration of the Rate of Wound Healing in Mice</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1980-07-01</date><risdate>1980</risdate><volume>77</volume><issue>7</issue><spage>4379</spage><epage>4381</epage><pages>4379-4381</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Earlier studies have shown that removal of the submandibular glands of mice retards the rate of contraction of experimentally induced wounds and that communal licking of wounds accelerates contraction in intact animals [Hutson, J. M., Niall, M., Evans, D. & Fowler, R. (1979) Nature (London) 279, 793-795]. In the light of the observation that nerve growth factor (NGF) is secreted in high concentrations in mouse saliva, we have studied the effect of topically applied high molecular weight nerve growth factor (HMW-NGF) upon the rate of wound contraction in sialoadenectomized animals. Results show that HMW-NGF significantly accelerates the rate of wound contraction and that this phenomenon is probably dependent upon the enzymic activity of the protein. Neither diisopropyl fluorophosphate-inactivated NGF nor 2.5S NGF [isolated according to Bocchini, V. & Angeletti, P. U. (1969) Proc. Natl. Acad. Sci. USA 64, 787-794] displays this biological activity. Thus, it may be that one of the physiological roles of NGF in saliva is to promote wound healing by the licking process.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>6933491</pmid><doi>10.1073/pnas.77.7.4379</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biochemistry Esters Male Mice Molecular weight Nerve Growth Factors - pharmacology Nerves Saliva Saliva - physiology Salivary glands Stimulation, Chemical Structure-Activity Relationship Submandibular Gland - physiology Wound healing Wound Healing - drug effects Wounds Zymogens |
| title | Nerve Growth Factor: Acceleration of the Rate of Wound Healing in Mice |
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