Lymphocyte Cooperation
Figure 1 illustrates schematically a mechanism that my colleagues and I believe may participate in the cooperative effect in antibody formation. Its essential feature is that thymus-derived cells, in response to antigen, release a soluble factor that is cytophilic for local macrophages and there bin...
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| Veröffentlicht in: | Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1971-01, Vol.176 (1045), p.425-426 |
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| container_issue | 1045 |
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| container_title | Proceedings of the Royal Society of London. Series B, Biological sciences |
| container_volume | 176 |
| creator | Lachmann, P. J. |
| description | Figure 1 illustrates schematically a mechanism that my colleagues and I believe may participate in the cooperative effect in antibody formation. Its essential feature is that thymus-derived cells, in response to antigen, release a soluble factor that is cytophilic for local macrophages and there binds antigen for presentation to the antibody-forming cell. Factors that inhibit macrophage migration (MIF) are known to be released in response to antigen from lymphocytes of animals showing delayed hypersensitivity (Bloom & Bennett 1966; David 1966). Delayed hypersensitivity reactions, and as far as is known MIF production, are mediated by thumus derived cells and in the hapten-carrier situation are largely carrier specific (Benacerraf & Levine 1962; Jankovic, Waksman & Arnason 1962; David & Schlossman 1968). |
| doi_str_mv | 10.1098/rspb.1971.0005 |
| format | Article |
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Delayed hypersensitivity reactions, and as far as is known MIF production, are mediated by thumus derived cells and in the hapten-carrier situation are largely carrier specific (Benacerraf & Levine 1962; Jankovic, Waksman & Arnason 1962; David & Schlossman 1968).</description><identifier>ISSN: 0080-4649</identifier><identifier>ISSN: 0950-1193</identifier><identifier>EISSN: 2053-9193</identifier><identifier>DOI: 10.1098/rspb.1971.0005</identifier><identifier>PMID: 4395782</identifier><language>eng</language><publisher>London: The Royal Society</publisher><subject>A Discussion on Cooperation between Lymphocytes in the Immune Response ; Animals ; Antibodies ; Antibody Formation ; Antibody-Producing Cells ; Antigens ; Cell Movement ; Delayed hypersensitivity ; Lymphocytes ; Macrophages ; Tuberculin</subject><ispartof>Proceedings of the Royal Society of London. 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Delayed hypersensitivity reactions, and as far as is known MIF production, are mediated by thumus derived cells and in the hapten-carrier situation are largely carrier specific (Benacerraf & Levine 1962; Jankovic, Waksman & Arnason 1962; David & Schlossman 1968).</description><subject>A Discussion on Cooperation between Lymphocytes in the Immune Response</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibody Formation</subject><subject>Antibody-Producing Cells</subject><subject>Antigens</subject><subject>Cell Movement</subject><subject>Delayed hypersensitivity</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Tuberculin</subject><issn>0080-4649</issn><issn>0950-1193</issn><issn>2053-9193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1LwzAUxYMoc05f9yAIPvnWepM0TfOowy8YKH48hzRNsWNbatIK9a83XcdARJ_Czf3dczgHoSmGGIPILp2v8xgLjmMAYHtoTIDRSGBB99EYIIMoSRNxiI68XwAkqRB0hEYJFYxnZIym825Vv1vdNeZ8Zm1tnGoquz5GB6VaenOyfSfo7fbmdXYfzR_vHmZX80hTQZtIY6LKhBplMCQkfAFRWnHGC0qAGKELrLHiac5yQjkuCdXBlQtTFiIzJqcTdDHo1s5-tMY3clV5bZZLtTa29TKDjBPKSADjAdTOeu9MKWtXrZTrJAbZFyH7ImRfhOyLCAdnW-U2X5lih2-Thz0d9s52IaHVlWk6ubCtW4fxb1X_39Xzy9M1Fkx8Yp5WoRImIaMYGE5IJr-qeiPXAzIAsvK-NXKD_bT57Xo6uC58Y90uCmeCcvoN_FeW-Q</recordid><startdate>19710112</startdate><enddate>19710112</enddate><creator>Lachmann, P. 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J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-c12af43eae104239302aca757d3202e9cd1c1a76b5b2371f23c78279efd98eeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>A Discussion on Cooperation between Lymphocytes in the Immune Response</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibody Formation</topic><topic>Antibody-Producing Cells</topic><topic>Antigens</topic><topic>Cell Movement</topic><topic>Delayed hypersensitivity</topic><topic>Lymphocytes</topic><topic>Macrophages</topic><topic>Tuberculin</topic><toplevel>online_resources</toplevel><creatorcontrib>Lachmann, P. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the Royal Society of London. Series B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lachmann, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte Cooperation</atitle><jtitle>Proceedings of the Royal Society of London. Series B, Biological sciences</jtitle><stitle>Proc. R. Soc. Lond. B</stitle><addtitle>Proc R Soc Lond B Biol Sci</addtitle><date>1971-01-12</date><risdate>1971</risdate><volume>176</volume><issue>1045</issue><spage>425</spage><epage>426</epage><pages>425-426</pages><issn>0080-4649</issn><issn>0950-1193</issn><eissn>2053-9193</eissn><abstract>Figure 1 illustrates schematically a mechanism that my colleagues and I believe may participate in the cooperative effect in antibody formation. Its essential feature is that thymus-derived cells, in response to antigen, release a soluble factor that is cytophilic for local macrophages and there binds antigen for presentation to the antibody-forming cell. Factors that inhibit macrophage migration (MIF) are known to be released in response to antigen from lymphocytes of animals showing delayed hypersensitivity (Bloom & Bennett 1966; David 1966). Delayed hypersensitivity reactions, and as far as is known MIF production, are mediated by thumus derived cells and in the hapten-carrier situation are largely carrier specific (Benacerraf & Levine 1962; Jankovic, Waksman & Arnason 1962; David & Schlossman 1968).</abstract><cop>London</cop><pub>The Royal Society</pub><pmid>4395782</pmid><doi>10.1098/rspb.1971.0005</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0080-4649 |
| ispartof | Proceedings of the Royal Society of London. Series B, Biological sciences, 1971-01, Vol.176 (1045), p.425-426 |
| issn | 0080-4649 0950-1193 2053-9193 |
| language | eng |
| recordid | cdi_jstor_primary_75937 |
| source | MEDLINE; Jstor Complete Legacy |
| subjects | A Discussion on Cooperation between Lymphocytes in the Immune Response Animals Antibodies Antibody Formation Antibody-Producing Cells Antigens Cell Movement Delayed hypersensitivity Lymphocytes Macrophages Tuberculin |
| title | Lymphocyte Cooperation |
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