Modulation of Ornithine Decarboxylase Activity in Escherichia coli by Positive and Negative Effectors

Two effectors of ornithine decarboxylase (ODC; L-ornithine carboxy-lyase, EC 4.1.1.17) have been extracted from an ODC- (speC-) mutant, Escherichia coli MA 255. One of these is an ODC inhibitor (Mr 15,000 ± 2000) that is labile to trypsin; its activity increases 20-fold in response to increased poly...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1978-10, Vol.75 (10), p.4699-4703
Hauptverfasser:	Kyriakidis, Dimitri A., Heller, John S., Canellakis, E. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carboxy-Lyases - metabolism Cell growth Chemical suspensions Chromatography Enzyme Activation Enzyme Inhibitors Enzymes Escherichia coli - enzymology Escherichia coli - growth & development Eukaryotic cells Macromolecules Mutation Ornithine Decarboxylase - metabolism Ornithine Decarboxylase Inhibitors Polyamines Polyamines - pharmacology Quaternary ammonium compounds Sulfates Titration
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