Tumor-Specific Transplantation Antigen: Use of the Ad2+ND1Hybrid Virus to Identify the Protein Responsible for Simian Virus 40 Tumor Rejection and Its Genetic Origin

Cells transformed by simian virus 40 (SV40) possess a tumor-specific transplantation antigen (TSTA) that has the property of immunizing animals against syngeneic tumor challenge. We find that the early SV40 DNA segment present in the human adenovirus 2 (Ad2)-SV40 hybrid, Ad2+ND1, is sufficient to in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1978-07, Vol.75 (7), p.3055-3059
Hauptverfasser:	Jay, Gilbert, Jay, Francis T., Chang, Chungming, Friedman, Robert M., Levine, Arthur S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell membranes Cell nucleus Cellular immunity Dosage Hybridity KB cells Nuclear membrane Tumors Viral tumor antigens Viruses
Online-Zugang:	Volltext
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