Electrophoretic Shift Mutants in Chinese Hamster Ovary Cells: Evidence for Genetic Diploidy

Electrophoretic shift mutants induced in Chinese hamster ovary (CHO) cells indicate that these cells are not extensively functionally hemizygotic. Therefore, effective haploidy is unsatisfactory as a general theory to explain the frequency of recessive mutants in this cell line. CHO cells were scree...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1978-04, Vol.75 (4), p.1919-1923
Hauptverfasser:	Siciliano, Michael J., Siciliano, Jeanette, Humphrey, Ronald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	550400 - Genetics 560121 - Radiation Effects on Cells- External Source- (-1987) Aneuploidy ANIMAL CELLS ANIMALS BASIC BIOLOGICAL SCIENCES BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOLOGICAL VARIABILITY CELL CULTURES Cell Line Cell lines CHO cells Chromosome Mapping Chromosomes Cricetinae Cricetulus - genetics Dimers DIPLOIDY ELECTROMAGNETIC RADIATION Electrophoresis, Starch Gel ENZYMES Enzymes - genetics Female GENES GENETIC EFFECTS Genetic loci Genetic mutation GENETIC RADIATION EFFECTS GENETIC VARIABILITY HAMSTERS Haploidy IRRADIATION Karyotyping MAMMALS Mutation MUTATIONS Ovary - enzymology PLOIDY RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RECESSIVE MUTATIONS RODENTS Somatic cells ULTRAVIOLET RADIATION VERTEBRATES
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