Human Leukocytic Pyrogen: Purification and Development of a Radioimmunoassay

Leukocytic pyrogen is a small endogenous protein that mediates fever. Because of the limitations of bioassays, circulating leukocytic pyrogen has not been demonstrated during fever in humans. The pyrogen was produced in vitro after phagocytosis of staphylococci by blood monocytes. Antibody against t...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1977-10, Vol.74 (10), p.4624-4627
Hauptverfasser:	Dinarello, Charles A., Renfer, Lois, Wolff, Sheldon M.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics ANIMALS ANTIBODIES Antibodies - isolation & purification Antiserum BETA DECAY RADIOISOTOPES Bioassay BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS Chromatography, Gel Chromatography, Ion Exchange DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES Fever Gels Humans Hydrogen-Ion Concentration Immunosorbent Techniques INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes ISOTOPE APPLICATIONS ISOTOPES LEUKOCYTES Leukocytes - analysis MAMMALS Methods Molecular weight Monocytes NUCLEI ODD-EVEN NUCLEI PURIFICATION Pyrogen PYROGENS Pyrogens - blood Pyrogens - immunology RABBITS Radioactive decay RADIOASSAY RADIOIMMUNOASSAY Radioimmunoassay - methods RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE TRACER TECHNIQUES VERTEBRATES
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