Blastic Transformation of Mouse Spleen Lymphocytes by a Water-Soluble Mitogen Extracted from Nocardia
A water-soluble extract of Nocardia markedly increased in vitro [3H]thymidine incorporation by mouse spleen lymphocytes. The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [3H]thymidine incorporati...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1974-05, Vol.71 (5), p.1602-1606 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Bona, Constantin Damais, Chantal Chedid, Louis |
| description | A water-soluble extract of Nocardia markedly increased in vitro [3H]thymidine incorporation by mouse spleen lymphocytes. The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [3H]thymidine incorporation and by electron microscopy have demonstrated that this preparation stimulates selectively mouse bone-marrow-derived cortisone-sensitive lymphocytes. This stimulation is related neither to a natural infection of mice with Nocardia organisms nor to the presence in Nocardia water-soluble mitogen of a lipopolysaccharide contaminant or of a lipopolysaccharide-like material. |
| doi_str_mv | 10.1073/pnas.71.5.1602 |
| format | Article |
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The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [3H]thymidine incorporation and by electron microscopy have demonstrated that this preparation stimulates selectively mouse bone-marrow-derived cortisone-sensitive lymphocytes. 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The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [3H]thymidine incorporation and by electron microscopy have demonstrated that this preparation stimulates selectively mouse bone-marrow-derived cortisone-sensitive lymphocytes. This stimulation is related neither to a natural infection of mice with Nocardia organisms nor to the presence in Nocardia water-soluble mitogen of a lipopolysaccharide contaminant or of a lipopolysaccharide-like material.</description><subject>B lymphocytes</subject><subject>Biological Sciences: Immunology</subject><subject>Lymphocytes</subject><subject>Mitogens</subject><subject>Nocardia</subject><subject>Plasma cells</subject><subject>Spleen</subject><subject>Spleen cells</subject><subject>Thymocytes</subject><subject>Toxicity</subject><subject>Tuberculin</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><recordid>eNp9kM1LwzAchoMoc35cPQhCTt5ak-ZzBw8qfsHUgxOPIU3TWWmbkmTi_nszNgdePIRAnufNL3kBOMEox0iQi6HXIRc4ZznmqNgBY4wmOON0gnbBGKFCZJIWdB8chPCJEJowiUZgRFnB0hoDe93qEBsDZ173oXa-07FxPXQ1fHKLYOHr0Frbw-myGz6cWUYbYLmEGr7raH326tpF2Vr41EQ3T9rtd_TaRFvB2rsOPjujfdXoI7BX6zbY481-CN7ubmc3D9n05f7x5mqaGYpIzDg3lBFkKy0JYkJIyQyWleYJlIVkNeNGsNIKTDnB1BQTVmqGUZm-y2rBySG4XN87LMrOVsb26TmtGnzTab9UTjfqL-mbDzV3X4pIWUia8vk6b7wLwdt6G8VIrepWq7qVwIqpVd0pcL4ZuDr_lbdc1Yu2jfY7JvHsPzHx0zX_DNH5rcAJlYT8AA2llBM</recordid><startdate>19740501</startdate><enddate>19740501</enddate><creator>Bona, Constantin</creator><creator>Damais, Chantal</creator><creator>Chedid, Louis</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19740501</creationdate><title>Blastic Transformation of Mouse Spleen Lymphocytes by a Water-Soluble Mitogen Extracted from Nocardia</title><author>Bona, Constantin ; Damais, Chantal ; Chedid, Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-66c4530eda830577885c18da666cb285f56c75be7146314c295ba510b6495f763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>B lymphocytes</topic><topic>Biological Sciences: Immunology</topic><topic>Lymphocytes</topic><topic>Mitogens</topic><topic>Nocardia</topic><topic>Plasma cells</topic><topic>Spleen</topic><topic>Spleen cells</topic><topic>Thymocytes</topic><topic>Toxicity</topic><topic>Tuberculin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bona, Constantin</creatorcontrib><creatorcontrib>Damais, Chantal</creatorcontrib><creatorcontrib>Chedid, Louis</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bona, Constantin</au><au>Damais, Chantal</au><au>Chedid, Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blastic Transformation of Mouse Spleen Lymphocytes by a Water-Soluble Mitogen Extracted from Nocardia</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><date>1974-05-01</date><risdate>1974</risdate><volume>71</volume><issue>5</issue><spage>1602</spage><epage>1606</epage><pages>1602-1606</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>A water-soluble extract of Nocardia markedly increased in vitro [3H]thymidine incorporation by mouse spleen lymphocytes. The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [3H]thymidine incorporation and by electron microscopy have demonstrated that this preparation stimulates selectively mouse bone-marrow-derived cortisone-sensitive lymphocytes. This stimulation is related neither to a natural infection of mice with Nocardia organisms nor to the presence in Nocardia water-soluble mitogen of a lipopolysaccharide contaminant or of a lipopolysaccharide-like material.</abstract><pub>National Academy of Sciences of the United States of America</pub><pmid>4525452</pmid><doi>10.1073/pnas.71.5.1602</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1974-05, Vol.71 (5), p.1602-1606 |
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| source | PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; JSTOR |
| subjects | B lymphocytes Biological Sciences: Immunology Lymphocytes Mitogens Nocardia Plasma cells Spleen Spleen cells Thymocytes Toxicity Tuberculin |
| title | Blastic Transformation of Mouse Spleen Lymphocytes by a Water-Soluble Mitogen Extracted from Nocardia |
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