Synthesis of DNA in Human Lymphocytes: Possible Control Mechanism

Partially purified, isolated nuclei from lymphocytes either stimulated or not stimulated by phytohemagglutinin can equally well synthesize DNA when [3H]dTTP is used as precursor. Studies of DNA polymerase activity in nuclei and cytoplasm from these cells showed that the enzyme can be detected in eit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1974-04, Vol.71 (4), p.1128-1132
Hauptverfasser:	Fridlender, Bertold R., Medrano, Estela, Mordoh, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Biological Sciences: Cell Biology Cell Fractionation Cell nucleus Cell Nucleus - drug effects Cell Nucleus - metabolism Cells Chemical suspensions Cycloheximide - pharmacology Cytarabine - pharmacology Cytoplasm - drug effects Cytoplasm - metabolism Dactinomycin - pharmacology DNA DNA - biosynthesis DNA Nucleotidyltransferases - metabolism DNA Replication - drug effects Enzymes Homogenization Humans Lectins - pharmacology Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - enzymology Lymphocytes - metabolism Nucleic acid precursors Stem cells Stimulation, Chemical Thymidine - metabolism Thymine Nucleotides - metabolism Tritium
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