Adrenalectomy and the Suppression of Memory by Puromycin
It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protect...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1970-05, Vol.66 (1), p.48-52 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Flexner, Josefa B. Flexner, Louis B. |
| description | It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude that adrenalectomy before training modifies factors necessary for the expression of memory and that this alteration makes puromycin ineffective in blocking memory. |
| doi_str_mv | 10.1073/pnas.66.1.48 |
| format | Article |
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Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude that adrenalectomy before training modifies factors necessary for the expression of memory and that this alteration makes puromycin ineffective in blocking memory.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.66.1.48</identifier><identifier>PMID: 4320463</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Adrenal Glands - physiology ; Adrenalectomy ; Adrenocorticotropic Hormone - physiology ; Animals ; Behavior, Animal - drug effects ; Biological Sciences: Physiology ; Female ; Male ; Memory ; Memory - drug effects ; Mice ; Puromycin - pharmacology ; Time Factors ; Training</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1970-05, Vol.66 (1), p.48-52</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-76baf2f10e1a02d5b23f779bc9cd1747c8d097754217316357795dd404e55e763</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/66/1.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/60182$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/60182$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4320463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flexner, Josefa B.</creatorcontrib><creatorcontrib>Flexner, Louis B.</creatorcontrib><title>Adrenalectomy and the Suppression of Memory by Puromycin</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude that adrenalectomy before training modifies factors necessary for the expression of memory and that this alteration makes puromycin ineffective in blocking memory.</description><subject>Adrenal Glands - physiology</subject><subject>Adrenalectomy</subject><subject>Adrenocorticotropic Hormone - physiology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological Sciences: Physiology</subject><subject>Female</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Puromycin - pharmacology</subject><subject>Time Factors</subject><subject>Training</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EgvLYmEBIGRATKdeOYzsDQ1XxkopAAmbLcRxIlcTBThD996Q0vAamO5zz3Xv1IbSPYYyBR2dNrfyYsTEeU7GGRhgSHDKawDoaARAeCkroFtr2fg4ASSxgE23SiABl0QiJSeZMrUqjW1stAlVnQftigoeuaZzxvrB1YPPg1lTWLYJ0Edx3rvd0Ue-ijVyV3uwNcwc9XV48Tq_D2d3VzXQyCzWlrA05S1VOcgwGKyBZnJIo5zxJdaIzzCnXIoOE85gSzCPMoriHcZZRoCaODWfRDjpf7W26tDKZNnXrVCkbV1TKLaRVhfxL6uJFPts3SQQDEff5kyHv7GtnfCurwmtTlqo2tvNSUNbfpqIXT1eidtZ7Z_LvGxjksmi5LFoyJrH81I9-__UtD832_Hjgy9QXHdIy78qyNe9trx3-r_X0YEXnvrXuBwMWJPoAC52ZIg</recordid><startdate>19700501</startdate><enddate>19700501</enddate><creator>Flexner, Josefa B.</creator><creator>Flexner, Louis B.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19700501</creationdate><title>Adrenalectomy and the Suppression of Memory by Puromycin</title><author>Flexner, Josefa B. ; Flexner, Louis B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-76baf2f10e1a02d5b23f779bc9cd1747c8d097754217316357795dd404e55e763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adrenal Glands - physiology</topic><topic>Adrenalectomy</topic><topic>Adrenocorticotropic Hormone - physiology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological Sciences: Physiology</topic><topic>Female</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Puromycin - pharmacology</topic><topic>Time Factors</topic><topic>Training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flexner, Josefa B.</creatorcontrib><creatorcontrib>Flexner, Louis B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flexner, Josefa B.</au><au>Flexner, Louis B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenalectomy and the Suppression of Memory by Puromycin</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1970-05-01</date><risdate>1970</risdate><volume>66</volume><issue>1</issue><spage>48</spage><epage>52</epage><pages>48-52</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude that adrenalectomy before training modifies factors necessary for the expression of memory and that this alteration makes puromycin ineffective in blocking memory.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>4320463</pmid><doi>10.1073/pnas.66.1.48</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1970-05, Vol.66 (1), p.48-52 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adrenal Glands - physiology Adrenalectomy Adrenocorticotropic Hormone - physiology Animals Behavior, Animal - drug effects Biological Sciences: Physiology Female Male Memory Memory - drug effects Mice Puromycin - pharmacology Time Factors Training |
| title | Adrenalectomy and the Suppression of Memory by Puromycin |
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