Amplification of Neuromuscular Transmission by Postjunctional Folds
Previously, suggestions have been made that postjunctional folds at the vertebrate motor end plate might, in some way, serve to enhance neuromuscular transmission. This suggestion was examined quantitatively using a model junction with geometry similar to that seen in mammalian ‘fast twitch’ muscles...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1994-12, Vol.258 (1353), p.321-326 |
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| container_title | Proceedings of the Royal Society. B, Biological sciences |
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| creator | Martin, A. R. |
| description | Previously, suggestions have been made that postjunctional folds at the vertebrate motor end plate might, in some way, serve to enhance neuromuscular transmission. This suggestion was examined quantitatively using a model junction with geometry similar to that seen in mammalian ‘fast twitch’ muscles. It was found that the depolarization produced at the top of an interfold by a quantum of acetylcholine is significantly greater than that produced in the absence of folds because of the series resistance of the interfold myoplasm. As a result, voltage-sensitive sodium channels in the postsynaptic membrane are activated more readily. In the model, activation of as few as four interfolds by eight quanta is sufficient for excitation to spread to the remainder of the muscle. With no folds, 19 quanta are required. |
| doi_str_mv | 10.1098/rspb.1994.0180 |
| format | Article |
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With no folds, 19 quanta are required.</description><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rspb.1994.0180</identifier><identifier>PMID: 21710792</identifier><language>eng</language><publisher>London: The Royal Society</publisher><subject>Animals ; Capacitance ; Cholinergic receptors ; Depolarization ; Electric Capacitance ; Electric Impedance ; Electrical Synapses - physiology ; Mammals ; Models, Biological ; Muscle, Skeletal - physiology ; Nerves ; Receptors ; Sodium ; Sodium channels ; Sodium Channels - physiology ; Synapses ; Transmitters ; Vertebrates</subject><ispartof>Proceedings of the Royal Society. 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R.</creatorcontrib><title>Amplification of Neuromuscular Transmission by Postjunctional Folds</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc. R. Soc. Lond. B</addtitle><addtitle>Proc. R. Soc. Lond. B</addtitle><description>Previously, suggestions have been made that postjunctional folds at the vertebrate motor end plate might, in some way, serve to enhance neuromuscular transmission. This suggestion was examined quantitatively using a model junction with geometry similar to that seen in mammalian ‘fast twitch’ muscles. It was found that the depolarization produced at the top of an interfold by a quantum of acetylcholine is significantly greater than that produced in the absence of folds because of the series resistance of the interfold myoplasm. As a result, voltage-sensitive sodium channels in the postsynaptic membrane are activated more readily. In the model, activation of as few as four interfolds by eight quanta is sufficient for excitation to spread to the remainder of the muscle. With no folds, 19 quanta are required.</description><subject>Animals</subject><subject>Capacitance</subject><subject>Cholinergic receptors</subject><subject>Depolarization</subject><subject>Electric Capacitance</subject><subject>Electric Impedance</subject><subject>Electrical Synapses - physiology</subject><subject>Mammals</subject><subject>Models, Biological</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nerves</subject><subject>Receptors</subject><subject>Sodium</subject><subject>Sodium channels</subject><subject>Sodium Channels - physiology</subject><subject>Synapses</subject><subject>Transmitters</subject><subject>Vertebrates</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1v1DAQxS0EokvhyoEDyo1TFn_EiX1C3RUFRAUrWuA4chyHekni1E6A5a_H2ZSVVoieLGt-b-bNG4SeErwkWIqXPvTlkkiZLTER-B5akKwgKZU8u48WWOY0FRmnJ-hRCFuMseSCP0QnlBQEF5Iu0Pqs7RtbW60G67rE1ckHM3rXjkGPjfLJlVddaG0IU7XcJRsXhu3Y6YlWTXLumio8Rg9q1QTz5PY9RZ_PX1-t36YXH9-8W59dpDrP-ZBWhuaskqVWlSwUrlTJKdeE6JKxStSVMqIwQuRYU4VLVpeaVbkqicl5zXles1P0Yu7be3czmjBANKZN06jOuDGAKDIqBaMyksuZ1N6F4E0Nvbet8jsgGKbcYMoNptxgyi0Knt-2HsvWVAf8b1ARYDPg3S7u6LQ1ww62bvQxhvD_tuEu1afLzSrC-AflwhLGGWDB4jxS4Bx-237fbgIgAhCPMBrYY8dj_p36bJ66DYPzh114PL-IxXQu2jCYX4ei8t8hL1jB4YvI4KsU7_HqcgWbyJOZv7bfrn9ab-Bol_jpfSj3BvfWGCVR8-pOzWRXu24w3XAkhHpsGuirmv0BLs3h4w</recordid><startdate>19941222</startdate><enddate>19941222</enddate><creator>Martin, A. R.</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941222</creationdate><title>Amplification of Neuromuscular Transmission by Postjunctional Folds</title><author>Martin, A. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c665t-de263d9bcad97a0dab525c11cb33d8fdae87e8860c2a0b3fbc3d6ab1e65f556f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Capacitance</topic><topic>Cholinergic receptors</topic><topic>Depolarization</topic><topic>Electric Capacitance</topic><topic>Electric Impedance</topic><topic>Electrical Synapses - physiology</topic><topic>Mammals</topic><topic>Models, Biological</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nerves</topic><topic>Receptors</topic><topic>Sodium</topic><topic>Sodium channels</topic><topic>Sodium Channels - physiology</topic><topic>Synapses</topic><topic>Transmitters</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, A. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, A. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amplification of Neuromuscular Transmission by Postjunctional Folds</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><stitle>Proc. R. Soc. Lond. B</stitle><addtitle>Proc. R. Soc. Lond. B</addtitle><date>1994-12-22</date><risdate>1994</risdate><volume>258</volume><issue>1353</issue><spage>321</spage><epage>326</epage><pages>321-326</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>Previously, suggestions have been made that postjunctional folds at the vertebrate motor end plate might, in some way, serve to enhance neuromuscular transmission. This suggestion was examined quantitatively using a model junction with geometry similar to that seen in mammalian ‘fast twitch’ muscles. It was found that the depolarization produced at the top of an interfold by a quantum of acetylcholine is significantly greater than that produced in the absence of folds because of the series resistance of the interfold myoplasm. As a result, voltage-sensitive sodium channels in the postsynaptic membrane are activated more readily. In the model, activation of as few as four interfolds by eight quanta is sufficient for excitation to spread to the remainder of the muscle. With no folds, 19 quanta are required.</abstract><cop>London</cop><pub>The Royal Society</pub><pmid>21710792</pmid><doi>10.1098/rspb.1994.0180</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0962-8452 |
| ispartof | Proceedings of the Royal Society. B, Biological sciences, 1994-12, Vol.258 (1353), p.321-326 |
| issn | 0962-8452 1471-2954 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Animals Capacitance Cholinergic receptors Depolarization Electric Capacitance Electric Impedance Electrical Synapses - physiology Mammals Models, Biological Muscle, Skeletal - physiology Nerves Receptors Sodium Sodium channels Sodium Channels - physiology Synapses Transmitters Vertebrates |
| title | Amplification of Neuromuscular Transmission by Postjunctional Folds |
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