Inhibition of Protein Phosphatase 2A Induces Serine/Threonine Phosphorylation, Subcellular Redistribution, and Functional Inhibition of STAT3

Signal transducers and activators of transcription (STATs) are rapidly phosphorylated on tyrosine residues in response to cytokine and growth factor stimulation of cell surface receptors. STATs hereafter are translocated to the nucleus where they act as transcription factors. Recent reports suggest...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-09, Vol.96 (19), p.10620-10625
Hauptverfasser:	Woetmann, Anders, Nielsen, Mette, Christensen, Soren T., Brockdorff, Johannes, Kaltoft, Keld, Engel, Anne-Marie, Skov, Soren, Brender, Christine, Geisler, Carsten, Svejgaard, Arne, Rygaard, Jorgen, Leick, Vagn, Odum, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	1-phosphatidylinositol 3-kinase Antibodies Biochemistry Biological Sciences Calcineurin Inhibitors CD4-Positive T-Lymphocytes - metabolism Cell lines Cell Nucleus - metabolism cyclosporin A Cyclosporine - pharmacology Cytokines Cytoplasm Cytoplasm - metabolism Deoxyribonucleic acid DNA DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology endothall thioanhydride Enzyme Inhibitors - pharmacology ERK protein Gene expression regulation Genetics Humans Immunology Lymphoma MAP kinase Microbiology Microscopy, Confocal Oxazoles - pharmacology p38 protein Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - physiology Phosphorylation Protein Phosphatase 2 Proteins Serine - metabolism Signal Transduction STAT3 Transcription Factor staurosporine Staurosporine - pharmacology T lymphocytes tautomycin Threonine - metabolism Trans-Activators - metabolism Trans-Activators - physiology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!