Upregulation of Lipogenesis and Protein Tyrosine Phosphatase-1B Expression in the Liver of Wistar Rats with Metabolic Syndrome Chronically Induced by Drinking Sucrose Water
Background: Establishing animal models with metabolic disorders similar to human metabolic syndrome (MS) is important. In terms of eliciting a full array of MS, we have previously shown that Wistar rats are more responsive to sucrose water drinking than are C57BL/6J mice. This study was aimed at inv...
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| Veröffentlicht in: | Annals of nutrition and metabolism 2011-01, Vol.57 (3/4), p.169-176 |
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| creator | Huang, Chun-Yin Lin, Yu-Shun Chen, Gou-Chun Huang, Hui-Ling Chuang, Shu-Han Chao, Pei-Min |
| description | Background: Establishing animal models with metabolic disorders similar to human metabolic syndrome (MS) is important. In terms of eliciting a full array of MS, we have previously shown that Wistar rats are more responsive to sucrose water drinking than are C57BL/6J mice. This study was aimed at investigating the underlying molecular mechanism of sucrose water-induced MS in Wistar rats. Methods: Male Wistar rats were divided into 2 groups (n = 8 for each group) which were given plain water (C group) or 30% sucrose water (SW group) to drink ad libitum. After 20 weeks, the transcriptional levels and protein translocation of hepatic sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP) as well as the protein levels of protein tyrosine phosphatase-1B (PTP-1B) in insulin-responsive tissues (liver, muscle, and adipose tissue) were measured. Results: The sucrose water regimen successfully elicited visceral obesity, hypertriglyceridemia, insulin resistance, and high blood pressure. The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP. Moreover, in the sucrose water-treated rats, protein levels of PTP-1B were significantly increased in liver and skeletal muscle but decreased in adipose tissue. Conclusion: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water. |
| doi_str_mv | 10.1159/000321966 |
| format | Article |
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In terms of eliciting a full array of MS, we have previously shown that Wistar rats are more responsive to sucrose water drinking than are C57BL/6J mice. This study was aimed at investigating the underlying molecular mechanism of sucrose water-induced MS in Wistar rats. Methods: Male Wistar rats were divided into 2 groups (n = 8 for each group) which were given plain water (C group) or 30% sucrose water (SW group) to drink ad libitum. After 20 weeks, the transcriptional levels and protein translocation of hepatic sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP) as well as the protein levels of protein tyrosine phosphatase-1B (PTP-1B) in insulin-responsive tissues (liver, muscle, and adipose tissue) were measured. Results: The sucrose water regimen successfully elicited visceral obesity, hypertriglyceridemia, insulin resistance, and high blood pressure. The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP. Moreover, in the sucrose water-treated rats, protein levels of PTP-1B were significantly increased in liver and skeletal muscle but decreased in adipose tissue. Conclusion: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.</description><identifier>ISSN: 0250-6807</identifier><identifier>EISSN: 1421-9697</identifier><identifier>DOI: 10.1159/000321966</identifier><identifier>PMID: 21079391</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adipose tissue ; Animal models ; Animals ; Blood Glucose - metabolism ; Blood pressure ; Dietary Sucrose - administration & dosage ; Dietary Sucrose - adverse effects ; Dietary Sucrose - metabolism ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Hypertension ; Insulin Resistance ; Lipogenesis - genetics ; Liver ; Liver - metabolism ; Male ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - metabolism ; Original Paper ; Protein Tyrosine Phosphatases - metabolism ; Random Allocation ; Rats ; Rats, Wistar ; Rodents ; Sterol Regulatory Element Binding Protein 1 - metabolism ; Sucrose ; Translocation ; Up-Regulation ; Water</subject><ispartof>Annals of nutrition and metabolism, 2011-01, Vol.57 (3/4), p.169-176</ispartof><rights>2010 S. Karger AG</rights><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-27447fe490b8f5ef9ffaaccf0a6e46570b9486d38f14420338200a9da462b5933</citedby><cites>FETCH-LOGICAL-c354t-27447fe490b8f5ef9ffaaccf0a6e46570b9486d38f14420338200a9da462b5933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48514066$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48514066$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2429,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21079391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chun-Yin</creatorcontrib><creatorcontrib>Lin, Yu-Shun</creatorcontrib><creatorcontrib>Chen, Gou-Chun</creatorcontrib><creatorcontrib>Huang, Hui-Ling</creatorcontrib><creatorcontrib>Chuang, Shu-Han</creatorcontrib><creatorcontrib>Chao, Pei-Min</creatorcontrib><title>Upregulation of Lipogenesis and Protein Tyrosine Phosphatase-1B Expression in the Liver of Wistar Rats with Metabolic Syndrome Chronically Induced by Drinking Sucrose Water</title><title>Annals of nutrition and metabolism</title><addtitle>Ann Nutr Metab</addtitle><description>Background: Establishing animal models with metabolic disorders similar to human metabolic syndrome (MS) is important. In terms of eliciting a full array of MS, we have previously shown that Wistar rats are more responsive to sucrose water drinking than are C57BL/6J mice. This study was aimed at investigating the underlying molecular mechanism of sucrose water-induced MS in Wistar rats. Methods: Male Wistar rats were divided into 2 groups (n = 8 for each group) which were given plain water (C group) or 30% sucrose water (SW group) to drink ad libitum. After 20 weeks, the transcriptional levels and protein translocation of hepatic sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP) as well as the protein levels of protein tyrosine phosphatase-1B (PTP-1B) in insulin-responsive tissues (liver, muscle, and adipose tissue) were measured. Results: The sucrose water regimen successfully elicited visceral obesity, hypertriglyceridemia, insulin resistance, and high blood pressure. The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP. Moreover, in the sucrose water-treated rats, protein levels of PTP-1B were significantly increased in liver and skeletal muscle but decreased in adipose tissue. Conclusion: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.</description><subject>Adipose tissue</subject><subject>Animal models</subject><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Dietary Sucrose - administration & dosage</subject><subject>Dietary Sucrose - adverse effects</subject><subject>Dietary Sucrose - metabolism</subject><subject>Disease Models, Animal</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Insulin Resistance</subject><subject>Lipogenesis - genetics</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Original Paper</subject><subject>Protein Tyrosine Phosphatases - metabolism</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sterol Regulatory Element Binding Protein 1 - metabolism</subject><subject>Sucrose</subject><subject>Translocation</subject><subject>Up-Regulation</subject><subject>Water</subject><issn>0250-6807</issn><issn>1421-9697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1u1DAURi0EokNhwR6QxQaxCFw7zo-XMBSoNIiKtuoycpLrGU8zdrAdIO_EQ-LRlEFi5cV37rGvP0KeMnjDWCHfAkDOmSzLe2TBBGeZLGV1nyyAF5CVNVQn5FEIWwDGa1E8JCecQSVzyRbk9_XocT0NKhpnqdN0ZUa3RovBBKpsTy-8i2gsvZq9C8Yivdi4MG5UVAEz9p6e_UqCEPbTiYobTIYf6PeqGxOi8vSbioH-NHFDv2BUrRtMRy9n23u3Q7rceGdNp4Zhpue2nzrsaTvTD97YW2PX9HLq0r1Ib1RE_5g80GoI-OTuPCXXH8-ulp-z1ddP58t3q6zLCxEzXglRaRQS2loXqKXWSnWdBlWiKIsKWinqss9rzYTgkOc1B1CyV6LkbSHz_JS8OnhH775PGGKzM6HDYVAW3RSa9Im5LEHyRL78j9y6ydv0uATVkldQiwS9PkD7VYJH3Yze7JSfGwbNvsDmWGBiX9wJp3aH_ZH821gCnh2AW-XX6I_Acf75Id6G6P6loi6YgJT_AW3VqgQ</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Huang, Chun-Yin</creator><creator>Lin, Yu-Shun</creator><creator>Chen, Gou-Chun</creator><creator>Huang, Hui-Ling</creator><creator>Chuang, Shu-Han</creator><creator>Chao, Pei-Min</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>Upregulation of Lipogenesis and Protein Tyrosine Phosphatase-1B Expression in the Liver of Wistar Rats with Metabolic Syndrome Chronically Induced by Drinking Sucrose Water</title><author>Huang, Chun-Yin ; Lin, Yu-Shun ; Chen, Gou-Chun ; Huang, Hui-Ling ; Chuang, Shu-Han ; Chao, Pei-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-27447fe490b8f5ef9ffaaccf0a6e46570b9486d38f14420338200a9da462b5933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose tissue</topic><topic>Animal models</topic><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Blood pressure</topic><topic>Dietary Sucrose - administration & dosage</topic><topic>Dietary Sucrose - adverse effects</topic><topic>Dietary Sucrose - metabolism</topic><topic>Disease Models, Animal</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Insulin Resistance</topic><topic>Lipogenesis - genetics</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Original Paper</topic><topic>Protein Tyrosine Phosphatases - metabolism</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sterol Regulatory Element Binding Protein 1 - metabolism</topic><topic>Sucrose</topic><topic>Translocation</topic><topic>Up-Regulation</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chun-Yin</creatorcontrib><creatorcontrib>Lin, Yu-Shun</creatorcontrib><creatorcontrib>Chen, Gou-Chun</creatorcontrib><creatorcontrib>Huang, Hui-Ling</creatorcontrib><creatorcontrib>Chuang, Shu-Han</creatorcontrib><creatorcontrib>Chao, Pei-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nutrition and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chun-Yin</au><au>Lin, Yu-Shun</au><au>Chen, Gou-Chun</au><au>Huang, Hui-Ling</au><au>Chuang, Shu-Han</au><au>Chao, Pei-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of Lipogenesis and Protein Tyrosine Phosphatase-1B Expression in the Liver of Wistar Rats with Metabolic Syndrome Chronically Induced by Drinking Sucrose Water</atitle><jtitle>Annals of nutrition and metabolism</jtitle><addtitle>Ann Nutr Metab</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>57</volume><issue>3/4</issue><spage>169</spage><epage>176</epage><pages>169-176</pages><issn>0250-6807</issn><eissn>1421-9697</eissn><abstract>Background: Establishing animal models with metabolic disorders similar to human metabolic syndrome (MS) is important. In terms of eliciting a full array of MS, we have previously shown that Wistar rats are more responsive to sucrose water drinking than are C57BL/6J mice. This study was aimed at investigating the underlying molecular mechanism of sucrose water-induced MS in Wistar rats. Methods: Male Wistar rats were divided into 2 groups (n = 8 for each group) which were given plain water (C group) or 30% sucrose water (SW group) to drink ad libitum. After 20 weeks, the transcriptional levels and protein translocation of hepatic sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP) as well as the protein levels of protein tyrosine phosphatase-1B (PTP-1B) in insulin-responsive tissues (liver, muscle, and adipose tissue) were measured. Results: The sucrose water regimen successfully elicited visceral obesity, hypertriglyceridemia, insulin resistance, and high blood pressure. The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP. Moreover, in the sucrose water-treated rats, protein levels of PTP-1B were significantly increased in liver and skeletal muscle but decreased in adipose tissue. Conclusion: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21079391</pmid><doi>10.1159/000321966</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of nutrition and metabolism, 2011-01, Vol.57 (3/4), p.169-176 |
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| subjects | Adipose tissue Animal models Animals Blood Glucose - metabolism Blood pressure Dietary Sucrose - administration & dosage Dietary Sucrose - adverse effects Dietary Sucrose - metabolism Disease Models, Animal Gene Expression Regulation Humans Hypertension Insulin Resistance Lipogenesis - genetics Liver Liver - metabolism Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - metabolism Original Paper Protein Tyrosine Phosphatases - metabolism Random Allocation Rats Rats, Wistar Rodents Sterol Regulatory Element Binding Protein 1 - metabolism Sucrose Translocation Up-Regulation Water |
| title | Upregulation of Lipogenesis and Protein Tyrosine Phosphatase-1B Expression in the Liver of Wistar Rats with Metabolic Syndrome Chronically Induced by Drinking Sucrose Water |
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