Folding Pathway of a Lattice Model for Proteins
The folding of a protein-like heteropolymer is studied by using direct simulation of a lattice model that folds rapidly to a well-defined "native" structure. The details of each molecular folding event depend on the random initial conformation as well as the random thermal fluctuations of...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1999-02, Vol.96 (4), p.1273-1278 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 96 |
| creator | Pande, Vijay S. Rokhsar, Daniel S. |
| description | The folding of a protein-like heteropolymer is studied by using direct simulation of a lattice model that folds rapidly to a well-defined "native" structure. The details of each molecular folding event depend on the random initial conformation as well as the random thermal fluctuations of the polymer. By analyzing the statistical properties of hundreds of folding events, a classical folding "pathway" for such a polymer is found that includes partially folded, on-pathway intermediates that are shown to be metastable equilibrium states of the polymer. These results are discussed in the context of the "classical" and "new" views of folding. |
| doi_str_mv | 10.1073/pnas.96.4.1273 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1999-02, Vol.96 (4), p.1273-1278 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Alma/SFX Local Collection; JSTOR |
| subjects | Biochemistry Biological Sciences Free energy Kinetics Mathematical minima Metastability Metastable atoms Modeling Models, Chemical Models, Molecular Monte Carlo Method Polymers Probability Protein Conformation Protein Denaturation Protein Folding Proteins Proteins - chemistry Proteins - metabolism Statistical variance Thermodynamics Trajectories |
| title | Folding Pathway of a Lattice Model for Proteins |
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