Specific Intercellular Binding of the β -amyloid Precursor Protein to the Presenilins Induces Intercellular Signaling: Its Significance for Alzheimer's Disease

Genetic evidence has implicated three proteins, the β -amyloid precursor protein (β -APP) and the two homologous presenilins (PS-1 and PS-2), in the etiology of Alzheimer's disease (AD). How these three proteins jointly contribute to AD, however, is not clear. Nor is any of their normal physiol...

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