Vaccination with Irradiated Autologous Melanoma Cells Engineered to Secrete Human Granulocyte--Macrophage Colony-Stimulating Factor Generates Potent Antitumor Immunity in Patients with Metastatic Melanoma

We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte--macrophage colony-stimulating factor in patients with metastatic melanoma. Immunization sites were intensely infiltrated with T...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-10, Vol.95 (22), p.13141-13146
Hauptverfasser:	Soiffer, Robert, Lynch, Thomas, Mihm, Martin, Jung, Ken, Rhuda, Catherine, Schmollinger, Jan C., Hodi, F. Stephen, Liebster, Laura, Lam, Prudence, Mentzer, Steven, Singer, Samuel, Tanabe, Kenneth K., Cosimi, A. Benedict, Duda, Rosemary, Sober, Arthur, Bhan, Atul, Daley, John, Neuberg, Donna, Parry, Gordon, Rokovich, Joseph, Richards, Laurie, Drayer, Jan, Berns, Anton, Clift, Shirley, Cohen, Lawrence K., Mulligan, Richard C., Dranoff, Glenn
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cancer Cancer Vaccines - adverse effects Cytokines - biosynthesis Cytokines - blood Dendritic Cells - immunology Dendritic Cells - pathology Eosinophils Eosinophils - immunology Eosinophils - pathology Genetic Engineering Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - genetics Humans Hypersensitivity, Delayed Immunization Immunology Lesions Lymphocytes Lymphocytes - immunology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Macrophages - immunology Macrophages - pathology Melanoma Melanoma - immunology Melanoma - pathology Melanoma - therapy Metastasis Neoplasm Metastasis Plasma cells T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - pathology Transplantation, Autologous Tumors Vaccination Vaccines
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