Indian Childhood Cirrhosis – A Heritable Disease

Pedigree charts of 220 families with an index case of Indian childhood cirrhosis, and 70 families of age-matched controls are analysed. Only 177 families were informative for segregation analysis. A single ascertainment model was used for analysis. The hypotheses of autosomal-recessive, partial sex-...

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Veröffentlicht in:	Human heredity 1982-01, Vol.32 (3), p.170-175
Hauptverfasser:	Kalra, V., Roy, S., Ghai, O. P., Jain, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Child, Preschool Genes, Dominant Genes, Recessive Genetic Linkage Humans India Liver Cirrhosis - genetics Original Paper Original Papers Pedigree Risk
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container_title	Human heredity
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creator	Kalra, V. Roy, S. Ghai, O. P. Jain, J. P.
description	Pedigree charts of 220 families with an index case of Indian childhood cirrhosis, and 70 families of age-matched controls are analysed. Only 177 families were informative for segregation analysis. A single ascertainment model was used for analysis. The hypotheses of autosomal-recessive, partial sex-linkage, and doubly recessive inheritance were found untenable. Multifactorial inheritance was found more plausible. The estimates of heritability of liability were 0.904 for propositi sib and 1.587 for propositi cousins, which indicates a strong role of heredity in the etiology of the disease.
doi_str_mv	10.1159/000153285
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P. ; Jain, J. P.</creator><creatorcontrib>Kalra, V. ; Roy, S. ; Ghai, O. P. ; Jain, J. P.</creatorcontrib><description>Pedigree charts of 220 families with an index case of Indian childhood cirrhosis, and 70 families of age-matched controls are analysed. Only 177 families were informative for segregation analysis. A single ascertainment model was used for analysis. The hypotheses of autosomal-recessive, partial sex-linkage, and doubly recessive inheritance were found untenable. Multifactorial inheritance was found more plausible. The estimates of heritability of liability were 0.904 for propositi sib and 1.587 for propositi cousins, which indicates a strong role of heredity in the etiology of the disease.</description><identifier>ISSN: 0001-5652</identifier><identifier>EISSN: 1423-0062</identifier><identifier>DOI: 10.1159/000153285</identifier><identifier>PMID: 7106781</identifier><language>eng</language><publisher>Basel, Switzerland: S. 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The estimates of heritability of liability were 0.904 for propositi sib and 1.587 for propositi cousins, which indicates a strong role of heredity in the etiology of the disease.</description><subject>Adult</subject><subject>Child, Preschool</subject><subject>Genes, Dominant</subject><subject>Genes, Recessive</subject><subject>Genetic Linkage</subject><subject>Humans</subject><subject>India</subject><subject>Liver Cirrhosis - genetics</subject><subject>Original Paper</subject><subject>Original Papers</subject><subject>Pedigree</subject><subject>Risk</subject><issn>0001-5652</issn><issn>1423-0062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkL9OwzAQxi0EKqUwsIMUCQmJIeA_sZ2MVSikUiUWmCM7PlND2hQ7Hdh4B96QJyFVSrswne6-3313-hA6J_iWEJ7dYYwJZzTlB2hIEspijAU9RMPNPOaC02N0EsJb16ZYsgEaSIKFTMkQ0enSOLWM8rmrzbxpTJQ77-dNcCH6-fqOxlEB3rVK1xDduwAqwCk6sqoOcLatI_TyMHnOi3j29DjNx7O4Ypy0sTDGZIxaDZrQLAWGtRLaGMmUynBiq4pKQ3SlRWIt0xa6xyW3VjIBXFjKRui691355mMNoS0XLlRQ12oJzTqUMiGpZKnowJserHwTggdbrrxbKP9ZElxu8il3-XTs5dZ0rRdgduQ2kE6_6PV35V_B753-1q_-lYti0hPlytj9kbfQNnso4QQTSSn7Bf3afeo</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Kalra, V.</creator><creator>Roy, S.</creator><creator>Ghai, O. 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The estimates of heritability of liability were 0.904 for propositi sib and 1.587 for propositi cousins, which indicates a strong role of heredity in the etiology of the disease.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger</pub><pmid>7106781</pmid><doi>10.1159/000153285</doi><tpages>6</tpages></addata></record>
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subjects	Adult Child, Preschool Genes, Dominant Genes, Recessive Genetic Linkage Humans India Liver Cirrhosis - genetics Original Paper Original Papers Pedigree Risk
title	Indian Childhood Cirrhosis – A Heritable Disease
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