Modulation of Ventricular Function through Gene Transfer in vivo

We used a catheter-based technique to achieve generalized cardiac gene transfer in vivo and to alter cardiac function by overexpressing phospholamban (PL) which regulates the activity of the sarcoplasmic reticulum Ca2+ATPase (SERCA2a). By using this approach, rat hearts were transduced in vivo with...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-04, Vol.95 (9), p.5251-5256
Hauptverfasser:	Hajjar, Roger J., Schmidt, Ulrich, Matsui, Takashi, Guerrero, J. Luis, Lee, Kyung-Han, Gwathmey, Judith K., Dec, G. William, Semigran, Marc J., Rosenzweig, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Adenoviruses, Human Animals Aorta Biological Sciences Calcium Calcium-Binding Proteins - genetics Cardiac output Catheterization Gene Expression Gene expression regulation Gene therapy Gene Transfer Techniques Genes Genetic Vectors Heart Heart - physiology Heart failure Hemodynamics Infections Isoproterenol - pharmacology Medical instruments Myocardium Rats Rodents Sarcoplasmic Reticulum - physiology Transduction, Genetic Transgenes Viruses
Online-Zugang:	Volltext
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