Activity-dependent FUS dysregulation disrupts synaptic homeostasis

The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative disorders that share similar clinical and pathological features. Both missense mutations and overexpression of wild-type FUS...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-11, Vol.111 (44), p.15613-15613
Hauptverfasser:	Sephton, Chantelle F., Tang, Amy A., Kulkarni, Ashwinikumar, West, James, Brooks, Mieu, Stubblefield, Jeremy J., Liu, Yun, Zhang, Michael Q., Green, Carla B., Huber, Kimberly M., Huang, Eric J., Herz, Joachim, Yu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Biological Sciences Dendrites - genetics Dendrites - metabolism Frontotemporal Lobar Degeneration - genetics Frontotemporal Lobar Degeneration - metabolism Frontotemporal Lobar Degeneration - pathology Humans Mice Mice, Transgenic Motor Activity - genetics Mutation Mutation, Missense Neuromuscular Junction - genetics Neuromuscular Junction - metabolism Neuromuscular Junction - pathology PNAS Plus PNAS Plus Significance Statements Proteins RNA-Binding Protein FUS - genetics RNA-Binding Protein FUS - metabolism Rodents Spine - metabolism Spine - pathology
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