A novel virus in swine is closely related to the human hepatitis E virus
A novel virus, designated swine hepatitis E virus (swine HEV), was identified in pigs. Swine HEV cross-reacts with antibody to the human HEV capsid antigen. Swine HEV is a ubiquitous agent and the majority of swine greater than or equal to 3 months of age in herds from the midwestern United States w...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (18), p.9860-9865 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Meng, X.J Purcell, R.H Halbur, P.G Lehman, J.R Webb, D.M Tsareva, T.S Haynes, J.S Thacker, B.J Emerson, S.U |
| description | A novel virus, designated swine hepatitis E virus (swine HEV), was identified in pigs. Swine HEV cross-reacts with antibody to the human HEV capsid antigen. Swine HEV is a ubiquitous agent and the majority of swine greater than or equal to 3 months of age in herds from the midwestern United States were seropositive. Young pigs naturally infected by swine HEV were clinically normal but had microscopic evidence of hepatitis, and developed viremia prior to seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription-PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79-80% sequence identity at the nucleotide level and 90-92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83-85% nucleotide sequence identity and 77-82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs |
| doi_str_mv | 10.1073/pnas.94.18.9860 |
| format | Article |
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Swine HEV cross-reacts with antibody to the human HEV capsid antigen. Swine HEV is a ubiquitous agent and the majority of swine greater than or equal to 3 months of age in herds from the midwestern United States were seropositive. Young pigs naturally infected by swine HEV were clinically normal but had microscopic evidence of hepatitis, and developed viremia prior to seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription-PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79-80% sequence identity at the nucleotide level and 90-92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83-85% nucleotide sequence identity and 77-82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.94.18.9860</identifier><identifier>PMID: 9275216</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; AMINO ACID SEQUENCES ; Amino acids ; ANIMAL VIRUSES ; Animals ; ANTIBODIES ; Antibodies, Viral - analysis ; Antibodies, Viral - immunology ; ANTICORPS ; ANTICUERPOS ; Biological Sciences ; Capsid ; CERDO ; CHEMICAL COMPOSITION ; COAT PROTEINS ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; ELISA ; Enzyme-Linked Immunosorbent Assay ; GENBANK/AF011921 ; GENE ; GENES ; Hepatitis ; Hepatitis E virus ; Hepatitis E virus - genetics ; Hepatitis E virus - immunology ; Hepatitis E virus - isolation & purification ; Herds ; Hogs ; Humans ; IMMUNE RESPONSE ; Infections ; MICROBIAL PROTEINS ; MOLECULAR SEQUENCE DATA ; NUCLEOTIDE SEQUENCE ; OPEN READING FRAMES ; PHYLOGENETICS ; Piglets ; Polymerase chain reaction ; PORCIN ; PROTEINAS MICROBIANAS ; PROTEINE MICROBIENNE ; REPONSE IMMUNITAIRE ; RESPUESTA INMUNOLOGICA ; SECUENCIA NUCLEOTIDICA ; Sequence Alignment ; SEQUENCE NUCLEOTIDIQUE ; SEROCONVERSION ; STRUCTURAL GENES ; SWINE ; Swine - virology ; SWINE HEPATITIS E VIRUS ; TEST ELISA ; UNCLASSIFIED VIRUSES ; VIRUS DE LOS ANIMALES ; VIRUS DES ANIMAUX ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (18), p.9860-9865</ispartof><rights>Copyright 1993-1997 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Sep 2, 1997</rights><rights>Copyright © 1997, The National Academy of Sciences of the USA 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-d3a65a19532d929dc4ec1867387b948c27d078fcad41813b1f99fa8242590ae43</citedby><cites>FETCH-LOGICAL-c606t-d3a65a19532d929dc4ec1867387b948c27d078fcad41813b1f99fa8242590ae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/94/18.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43117$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43117$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9275216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, X.J</creatorcontrib><creatorcontrib>Purcell, R.H</creatorcontrib><creatorcontrib>Halbur, P.G</creatorcontrib><creatorcontrib>Lehman, J.R</creatorcontrib><creatorcontrib>Webb, D.M</creatorcontrib><creatorcontrib>Tsareva, T.S</creatorcontrib><creatorcontrib>Haynes, J.S</creatorcontrib><creatorcontrib>Thacker, B.J</creatorcontrib><creatorcontrib>Emerson, S.U</creatorcontrib><title>A novel virus in swine is closely related to the human hepatitis E virus</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>A novel virus, designated swine hepatitis E virus (swine HEV), was identified in pigs. Swine HEV cross-reacts with antibody to the human HEV capsid antigen. Swine HEV is a ubiquitous agent and the majority of swine greater than or equal to 3 months of age in herds from the midwestern United States were seropositive. Young pigs naturally infected by swine HEV were clinically normal but had microscopic evidence of hepatitis, and developed viremia prior to seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription-PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79-80% sequence identity at the nucleotide level and 90-92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83-85% nucleotide sequence identity and 77-82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs</description><subject>Amino Acid Sequence</subject><subject>AMINO ACID SEQUENCES</subject><subject>Amino acids</subject><subject>ANIMAL VIRUSES</subject><subject>Animals</subject><subject>ANTIBODIES</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibodies, Viral - immunology</subject><subject>ANTICORPS</subject><subject>ANTICUERPOS</subject><subject>Biological Sciences</subject><subject>Capsid</subject><subject>CERDO</subject><subject>CHEMICAL COMPOSITION</subject><subject>COAT PROTEINS</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>GENBANK/AF011921</subject><subject>GENE</subject><subject>GENES</subject><subject>Hepatitis</subject><subject>Hepatitis E virus</subject><subject>Hepatitis E virus - genetics</subject><subject>Hepatitis E virus - immunology</subject><subject>Hepatitis E virus - isolation & purification</subject><subject>Herds</subject><subject>Hogs</subject><subject>Humans</subject><subject>IMMUNE RESPONSE</subject><subject>Infections</subject><subject>MICROBIAL PROTEINS</subject><subject>MOLECULAR SEQUENCE DATA</subject><subject>NUCLEOTIDE SEQUENCE</subject><subject>OPEN READING FRAMES</subject><subject>PHYLOGENETICS</subject><subject>Piglets</subject><subject>Polymerase chain reaction</subject><subject>PORCIN</subject><subject>PROTEINAS MICROBIANAS</subject><subject>PROTEINE MICROBIENNE</subject><subject>REPONSE IMMUNITAIRE</subject><subject>RESPUESTA INMUNOLOGICA</subject><subject>SECUENCIA NUCLEOTIDICA</subject><subject>Sequence Alignment</subject><subject>SEQUENCE NUCLEOTIDIQUE</subject><subject>SEROCONVERSION</subject><subject>STRUCTURAL GENES</subject><subject>SWINE</subject><subject>Swine - virology</subject><subject>SWINE HEPATITIS E VIRUS</subject><subject>TEST ELISA</subject><subject>UNCLASSIFIED VIRUSES</subject><subject>VIRUS DE LOS ANIMALES</subject><subject>VIRUS DES ANIMAUX</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhUcIVNLCGgkJZHUBq6T32p6xLbGpqkKRKrGAri1nxtM4csbB9gT673FINDwWsLqL8537OlX1AmGBINjFdjBpofgC5ULJBh5VMwSF84YreFzNAKiYS0750-o0pTUAqFrCSXWiqKgpNrPq5pIMYWc92bk4JuIGkr65wRKXSOtDsv6BROtNth3JgeSVJatxYwaysluTXS7Y9cH6rHrSG5_s82M9q-7eX3-5upnffvrw8erydt420OR5x0xTG1Q1o52iqmu5bVE2gkmxVFy2VHQgZN-ajqNEtsReqd5IymmtwFjOzqp3h77bcbmxXWuHHI3X2-g2Jj7oYJz-UxncSt-HnaaMSlrsb472GL6ONmW9cam13pvBhjFpoWgZDPy_IAqsRYNQwPO_wHUY41B-oCkg44A_oYsD1MaQUrT9tDCC3gep90FqxTVKvQ-yOF79fufEH5Mr-tujvjdO6tRA96P32X7PhXz9T7IALw_AOuUQJ4IzRPFrj94Ebe6jS_ruMyoloBzPKfsBKmjCoQ</recordid><startdate>19970902</startdate><enddate>19970902</enddate><creator>Meng, X.J</creator><creator>Purcell, R.H</creator><creator>Halbur, P.G</creator><creator>Lehman, J.R</creator><creator>Webb, D.M</creator><creator>Tsareva, T.S</creator><creator>Haynes, J.S</creator><creator>Thacker, B.J</creator><creator>Emerson, S.U</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences of the USA</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19970902</creationdate><title>A novel virus in swine is closely related to the human hepatitis E virus</title><author>Meng, X.J ; 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Swine HEV cross-reacts with antibody to the human HEV capsid antigen. Swine HEV is a ubiquitous agent and the majority of swine greater than or equal to 3 months of age in herds from the midwestern United States were seropositive. Young pigs naturally infected by swine HEV were clinically normal but had microscopic evidence of hepatitis, and developed viremia prior to seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription-PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79-80% sequence identity at the nucleotide level and 90-92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83-85% nucleotide sequence identity and 77-82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>9275216</pmid><doi>10.1073/pnas.94.18.9860</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (18), p.9860-9865 |
| issn | 0027-8424 1091-6490 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence AMINO ACID SEQUENCES Amino acids ANIMAL VIRUSES Animals ANTIBODIES Antibodies, Viral - analysis Antibodies, Viral - immunology ANTICORPS ANTICUERPOS Biological Sciences Capsid CERDO CHEMICAL COMPOSITION COAT PROTEINS COMPOSICION QUIMICA COMPOSITION CHIMIQUE ELISA Enzyme-Linked Immunosorbent Assay GENBANK/AF011921 GENE GENES Hepatitis Hepatitis E virus Hepatitis E virus - genetics Hepatitis E virus - immunology Hepatitis E virus - isolation & purification Herds Hogs Humans IMMUNE RESPONSE Infections MICROBIAL PROTEINS MOLECULAR SEQUENCE DATA NUCLEOTIDE SEQUENCE OPEN READING FRAMES PHYLOGENETICS Piglets Polymerase chain reaction PORCIN PROTEINAS MICROBIANAS PROTEINE MICROBIENNE REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA SECUENCIA NUCLEOTIDICA Sequence Alignment SEQUENCE NUCLEOTIDIQUE SEROCONVERSION STRUCTURAL GENES SWINE Swine - virology SWINE HEPATITIS E VIRUS TEST ELISA UNCLASSIFIED VIRUSES VIRUS DE LOS ANIMALES VIRUS DES ANIMAUX Viruses |
| title | A novel virus in swine is closely related to the human hepatitis E virus |
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