Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma

Central nervous system tumors carry grave clinical prognoses due to limited effectiveness of surgical resection, radiation, and chemotherapy. Thus, improved strategies for brain tumor visualization and targeted treatment are critically needed. We demonstrate that mouse cerebellar medulloblastoma (MB...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-09, Vol.110 (36), p.14598-14603
Hauptverfasser:	Moore, Sarah J., Gephart, Melanie G. Hayden, Bergen, Jamie M., Su, YouRong S., Rayburn, Helen, Scott, Matthew P., Cochran, Jennifer R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain cancer Brain neoplasms Cancer Cerebellar Neoplasms - diagnosis Cerebellar Neoplasms - genetics Cerebellar Neoplasms - metabolism Chemotherapy Cystine-Knot Miniproteins - chemistry Cystine-Knot Miniproteins - genetics Cystine-Knot Miniproteins - metabolism Diagnostic Imaging - methods Dyes Female Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Imaging Integrin alpha5beta1 - metabolism Integrins Male Medulloblastoma Medulloblastoma - diagnosis Medulloblastoma - genetics Medulloblastoma - metabolism Mice Mice, Knockout Mice, Nude Mice, Transgenic Microscopy, Fluorescence Molecular imaging Molecular Imaging - methods Molecules Nervous system Neuroimaging Patched Receptors Peptides Protein Binding Protein Engineering Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Rodents Sensitivity and Specificity Tissues Tumors
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