functional genomic perspective on human well-being
To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psycho...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (33), p.13684-13689 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Fredrickson, Barbara L. Grewen, Karen M. Coffey, Kimberly A. Algoe, Sara B. Firestine, Ann M. Arevalo, Jesusa M. G. Ma, Jeffrey Cole, Steven W. |
| description | To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences. |
| doi_str_mv | 10.1073/pnas.1305419110 |
| format | Article |
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G. ; Ma, Jeffrey ; Cole, Steven W.</creator><creatorcontrib>Fredrickson, Barbara L. ; Grewen, Karen M. ; Coffey, Kimberly A. ; Algoe, Sara B. ; Firestine, Ann M. ; Arevalo, Jesusa M. G. ; Ma, Jeffrey ; Cole, Steven W.</creatorcontrib><description>To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1305419110</identifier><identifier>PMID: 23898182</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences</publisher><subject>Adult ; adults ; Antibodies ; Antibodies - genetics ; Antibodies - metabolism ; B-lymphocytes ; Bioinformatics ; Biological and medical sciences ; Biological Sciences ; Computational Biology ; dendritic cells ; Depressive disorders ; Fundamental and applied biological sciences. Psychology ; Gene expression ; gene expression regulation ; Gene Regulatory Networks - genetics ; Genes ; Genome, Human - genetics ; Genomes ; Genomics ; Happiness ; Humans ; Immunoglobulins ; Interferon Type I - genetics ; Interferon Type I - metabolism ; Language ; Leukocytes ; Leukocytes, Mononuclear ; mental depression ; Middle Aged ; Miscellaneous ; Models, Psychological ; monocytes ; NF-kappa B - metabolism ; North Carolina ; people ; Pleasure ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Quality of life ; Quality of Life - psychology ; regulator genes ; Surveys and Questionnaires ; transcription (genetics) ; Transcription Factor AP-1 - metabolism ; transcription factor NF-kappa B ; Transcription factors ; Transcription Factors - metabolism ; Transcriptome ; Wellbeing</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (33), p.13684-13689</ispartof><rights>copyright © 1993-2008 National Academy of Sciences of the United States of America</rights><rights>2015 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Aug 13, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-b7d43e6211b57f647e8c7eec1910e73e4e49133e3861edd43a3903f821490f0d3</citedby><cites>FETCH-LOGICAL-c621t-b7d43e6211b57f647e8c7eec1910e73e4e49133e3861edd43a3903f821490f0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/110/33.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42712967$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42712967$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27805864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23898182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fredrickson, Barbara L.</creatorcontrib><creatorcontrib>Grewen, Karen M.</creatorcontrib><creatorcontrib>Coffey, Kimberly A.</creatorcontrib><creatorcontrib>Algoe, Sara B.</creatorcontrib><creatorcontrib>Firestine, Ann M.</creatorcontrib><creatorcontrib>Arevalo, Jesusa M. G.</creatorcontrib><creatorcontrib>Ma, Jeffrey</creatorcontrib><creatorcontrib>Cole, Steven W.</creatorcontrib><title>functional genomic perspective on human well-being</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.</description><subject>Adult</subject><subject>adults</subject><subject>Antibodies</subject><subject>Antibodies - genetics</subject><subject>Antibodies - metabolism</subject><subject>B-lymphocytes</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biological Sciences</subject><subject>Computational Biology</subject><subject>dendritic cells</subject><subject>Depressive disorders</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>gene expression regulation</subject><subject>Gene Regulatory Networks - genetics</subject><subject>Genes</subject><subject>Genome, Human - genetics</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Happiness</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Interferon Type I - genetics</subject><subject>Interferon Type I - metabolism</subject><subject>Language</subject><subject>Leukocytes</subject><subject>Leukocytes, Mononuclear</subject><subject>mental depression</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Models, Psychological</subject><subject>monocytes</subject><subject>NF-kappa B - metabolism</subject><subject>North Carolina</subject><subject>people</subject><subject>Pleasure</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>regulator genes</subject><subject>Surveys and Questionnaires</subject><subject>transcription (genetics)</subject><subject>Transcription Factor AP-1 - metabolism</subject><subject>transcription factor NF-kappa B</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptome</subject><subject>Wellbeing</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS1ERZfCmRMQCSH1knb8EX9cKqEKKFIlDtCz5fVOtlkldrCTIv57vN1lW7hwsuX5ed6beYS8onBGQfHzMbh8Rjk0ghpK4QlZUDC0lsLAU7IAYKrWgolj8jznDQCYRsMzcsy4NppqtiCsnYOfuhhcX60xxKHz1Ygpj1he77CKobqdBxeqn9j39RK7sH5BjlrXZ3y5P0_IzaeP3y-v6uuvn79cfriuvWR0qpdqJTiWK102qpVCofYK0RejgIqjQGEo58i1pLgqrOMGeKsZLeZbWPETcrHrO87LAVcew5Rcb8fUDS79stF19u9K6G7tOt5ZroQ0zJQGp_sGKf6YMU926LIvc7iAcc6WauCgG22a_6NliZxxoUVB3_2DbuKcyv7uqaYBoyUU6nxH-RRzTtgefFOw2-jsNjr7EF358ebxuAf-T1YFeL8HXPaub5MLvssPnNLQaLk1WO25rcJBtuhyXgTl_Qyvd8gmTzEdGMEUZUaqUn-7q7cuWrdORebmGwMqAaiAhiv-G32RvSo</recordid><startdate>20130813</startdate><enddate>20130813</enddate><creator>Fredrickson, Barbara L.</creator><creator>Grewen, Karen M.</creator><creator>Coffey, Kimberly A.</creator><creator>Algoe, Sara B.</creator><creator>Firestine, Ann M.</creator><creator>Arevalo, Jesusa M. G.</creator><creator>Ma, Jeffrey</creator><creator>Cole, Steven W.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130813</creationdate><title>functional genomic perspective on human well-being</title><author>Fredrickson, Barbara L. ; Grewen, Karen M. ; Coffey, Kimberly A. ; Algoe, Sara B. ; Firestine, Ann M. ; Arevalo, Jesusa M. G. ; Ma, Jeffrey ; Cole, Steven W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c621t-b7d43e6211b57f647e8c7eec1910e73e4e49133e3861edd43a3903f821490f0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>adults</topic><topic>Antibodies</topic><topic>Antibodies - genetics</topic><topic>Antibodies - metabolism</topic><topic>B-lymphocytes</topic><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Biological Sciences</topic><topic>Computational Biology</topic><topic>dendritic cells</topic><topic>Depressive disorders</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>gene expression regulation</topic><topic>Gene Regulatory Networks - genetics</topic><topic>Genes</topic><topic>Genome, Human - genetics</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Happiness</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Interferon Type I - genetics</topic><topic>Interferon Type I - metabolism</topic><topic>Language</topic><topic>Leukocytes</topic><topic>Leukocytes, Mononuclear</topic><topic>mental depression</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Models, Psychological</topic><topic>monocytes</topic><topic>NF-kappa B - metabolism</topic><topic>North Carolina</topic><topic>people</topic><topic>Pleasure</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>regulator genes</topic><topic>Surveys and Questionnaires</topic><topic>transcription (genetics)</topic><topic>Transcription Factor AP-1 - metabolism</topic><topic>transcription factor NF-kappa B</topic><topic>Transcription factors</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptome</topic><topic>Wellbeing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fredrickson, Barbara L.</creatorcontrib><creatorcontrib>Grewen, Karen M.</creatorcontrib><creatorcontrib>Coffey, Kimberly A.</creatorcontrib><creatorcontrib>Algoe, Sara B.</creatorcontrib><creatorcontrib>Firestine, Ann M.</creatorcontrib><creatorcontrib>Arevalo, Jesusa M. 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G.</au><au>Ma, Jeffrey</au><au>Cole, Steven W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>functional genomic perspective on human well-being</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2013-08-13</date><risdate>2013</risdate><volume>110</volume><issue>33</issue><spage>13684</spage><epage>13689</epage><pages>13684-13689</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences</pub><pmid>23898182</pmid><doi>10.1073/pnas.1305419110</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult adults Antibodies Antibodies - genetics Antibodies - metabolism B-lymphocytes Bioinformatics Biological and medical sciences Biological Sciences Computational Biology dendritic cells Depressive disorders Fundamental and applied biological sciences. Psychology Gene expression gene expression regulation Gene Regulatory Networks - genetics Genes Genome, Human - genetics Genomes Genomics Happiness Humans Immunoglobulins Interferon Type I - genetics Interferon Type I - metabolism Language Leukocytes Leukocytes, Mononuclear mental depression Middle Aged Miscellaneous Models, Psychological monocytes NF-kappa B - metabolism North Carolina people Pleasure Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Quality of life Quality of Life - psychology regulator genes Surveys and Questionnaires transcription (genetics) Transcription Factor AP-1 - metabolism transcription factor NF-kappa B Transcription factors Transcription Factors - metabolism Transcriptome Wellbeing |
| title | functional genomic perspective on human well-being |
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