Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

The physiological functions of hydrogen sulfide (H ₂S) include vasorelaxation, stimulation of cellular bioenergetics, and promotion of angiogenesis. Analysis of human colon cancer biopsies and patient-matched normal margin mucosa revealed the selective up-regulation of the H ₂S-producing enzyme cyst...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-07, Vol.110 (30), p.12474-12479
Hauptverfasser:	Szabo, Csaba, Coletta, Ciro, Chao, Celia, Módis, Katalin, Szczesny, Bartosz, Papapetropoulos, Andreas, Hellmich, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate aminooxyacetic acid Angiogenesis Animals antineoplastic agents Biological Sciences biopsy blood blood flow Cell growth Cell lines cell movement Cell Proliferation coculture colon Colonic Neoplasms - blood supply Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer colorectal neoplasms cystathionine beta-synthase Cystathionine beta-Synthase - metabolism cystathionine gamma-lyase cytosol Endothelial cells Energy Metabolism Epithelial cells Female glycolysis HCT116 cells HT29 Cells Humans Hydrogen hydrogen sulfide Hydrogen Sulfide - metabolism Mice Mice, Inbred BALB C mitochondrial membrane mucosa neoplasm cells Neovascularization, Pathologic oxygen consumption Sulfides Tumors vasodilation
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