Mutation of the ATP-gated P2X₂ receptor leads to progressive hearing loss and increased susceptibility to noise

Age-related hearing loss and noise-induced hearing loss are major causes of human morbidity. Here we used genetics and functional studies to show that a shared cause of these disorders may be loss of function of the ATP-gated P2X ₂ receptor (ligand-gated ion channel, purinergic receptor 2) that is e...

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