Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes

A monoclonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of covalent αDEC205–antigen adducts. These adducts can induce antigen-specific T-cell immune responses or tolerance. We exploit the transpeptidase act...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (4), p.1428-1433
Hauptverfasser:	Swee, Lee Kim, Guimaraes, Carla P., Sehrawat, Sharvan, Spooner, Eric, Barrasa, M. Inmaculada, Ploegh, Hidde L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Amino Acid Sequence amino acids Aminoacyltransferases - metabolism Animals Antibodies Antigen Presentation Antigens Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Antigens, Viral - chemistry Antigens, Viral - genetics Antigens, Viral - immunology Bacterial Proteins - metabolism Biological Sciences CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - immunology Cysteine Endopeptidases - metabolism Cytoplasm Dendritic cells Epitopes Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Herpesviridae Infections - immunology Herpesviridae Infections - prevention & control Histocompatibility Antigens Class I - metabolism immune response Immunization Immunoconjugates - genetics Immunoconjugates - immunology Immunoconjugates - metabolism lectins Lectins, C-Type - chemistry Lectins, C-Type - genetics Lectins, C-Type - immunology Lectins, C-Type - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Minor Histocompatibility Antigens Molecular Sequence Data monoclonal antibodies peptide libraries Proteasome Endopeptidase Complex - metabolism Protein Engineering Proteins Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Rhadinovirus - genetics Rhadinovirus - immunology T lymphocyte epitopes T lymphocytes Tumor Virus Infections - immunology Tumor Virus Infections - prevention & control Vaccines, Subunit - genetics Vaccines, Subunit - immunology viral load Viral Vaccines - genetics Viral Vaccines - immunology viruses
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