Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative
Tomato breeding has been tremendously efficient in increasing fruit quality and quantity but did not focus on improving herbivore resistance. The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with the aim to obtain he...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2012-12, Vol.109 (49), p.20124-20129 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 109 |
| creator | Bleeker, Petra M Mirabella, Rossana Diergaarde, Paul J VanDoorn, Arjen Tissier, Alain Kant, Merijn R Prins, Marcel de Vos, Martin Haring, Michel A Schuurink, Robert C |
| description | Tomato breeding has been tremendously efficient in increasing fruit quality and quantity but did not focus on improving herbivore resistance. The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with the aim to obtain herbivore resistance. 7-Epizingiberene is a specific sesquiterpene with toxic and repellent properties that is produced and stored in glandular trichomes. We identified 7-epizingiberene synthase (ShZIS) that belongs to a new class of sesquiterpene synthases, exclusively using Z-Z- farnesyl-diphosphate (zFPP) in plastids, probably arisen through neo-functionalization of a common ancestor. Expression of the ShZIS and zFPP synthases in the glandular trichomes of cultivated tomato resulted in the production of 7-epizingiberene. These tomatoes gained resistance to several herbivores that are pests of tomato. Hence, introduction of this sesquiterpene biosynthetic pathway into cultivated tomatoes resulted in improved herbivore resistance. |
| doi_str_mv | 10.1073/pnas.1208756109 |
| format | Article |
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The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with the aim to obtain herbivore resistance. 7-Epizingiberene is a specific sesquiterpene with toxic and repellent properties that is produced and stored in glandular trichomes. We identified 7-epizingiberene synthase (ShZIS) that belongs to a new class of sesquiterpene synthases, exclusively using Z-Z- farnesyl-diphosphate (zFPP) in plastids, probably arisen through neo-functionalization of a common ancestor. Expression of the ShZIS and zFPP synthases in the glandular trichomes of cultivated tomato resulted in the production of 7-epizingiberene. These tomatoes gained resistance to several herbivores that are pests of tomato. Hence, introduction of this sesquiterpene biosynthetic pathway into cultivated tomatoes resulted in improved herbivore resistance.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1208756109</identifier><identifier>PMID: 23169639</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Alkyl and Aryl Transferases - genetics ; Alkyl and Aryl Transferases - metabolism ; Analysis of Variance ; Animals ; biochemical pathways ; Biological Sciences ; Biosynthesis ; Biosynthetic Pathways - genetics ; breeding ; Breeding - methods ; Cloning, Molecular ; Eggs ; Feeding Behavior - physiology ; fruit quality ; Gas Chromatography-Mass Spectrometry ; greenhouses ; Hemiptera - physiology ; Herbivores ; Herbivory - immunology ; Lycopersicon esculentum - genetics ; Lycopersicon esculentum - immunology ; Lycopersicon esculentum - parasitology ; Metabolic Engineering - methods ; Mites ; Monoterpenes ; pests ; Plants ; Plastids ; Polyisoprenyl Phosphates ; Real-Time Polymerase Chain Reaction ; Sesquiterpenes ; Sesquiterpenes - immunology ; Sesquiterpenes - metabolism ; sesquiterpenoids ; Spiders ; Terpenes ; Tetranychidae - physiology ; Tomatoes ; toxicity ; Transgenic plants ; Trichomes</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (49), p.20124-20129</ispartof><rights>copyright © 1993-2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Dec 4, 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-ece05e8bb3d722420f8955488a05ccd88d2582fdfbc1a77bebc68b388cfd81ec3</citedby><cites>FETCH-LOGICAL-c525t-ece05e8bb3d722420f8955488a05ccd88d2582fdfbc1a77bebc68b388cfd81ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/109/49.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41830476$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41830476$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23169639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bleeker, Petra M</creatorcontrib><creatorcontrib>Mirabella, Rossana</creatorcontrib><creatorcontrib>Diergaarde, Paul J</creatorcontrib><creatorcontrib>VanDoorn, Arjen</creatorcontrib><creatorcontrib>Tissier, Alain</creatorcontrib><creatorcontrib>Kant, Merijn R</creatorcontrib><creatorcontrib>Prins, Marcel</creatorcontrib><creatorcontrib>de Vos, Martin</creatorcontrib><creatorcontrib>Haring, Michel A</creatorcontrib><creatorcontrib>Schuurink, Robert C</creatorcontrib><title>Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Tomato breeding has been tremendously efficient in increasing fruit quality and quantity but did not focus on improving herbivore resistance. The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with the aim to obtain herbivore resistance. 7-Epizingiberene is a specific sesquiterpene with toxic and repellent properties that is produced and stored in glandular trichomes. We identified 7-epizingiberene synthase (ShZIS) that belongs to a new class of sesquiterpene synthases, exclusively using Z-Z- farnesyl-diphosphate (zFPP) in plastids, probably arisen through neo-functionalization of a common ancestor. Expression of the ShZIS and zFPP synthases in the glandular trichomes of cultivated tomato resulted in the production of 7-epizingiberene. These tomatoes gained resistance to several herbivores that are pests of tomato. Hence, introduction of this sesquiterpene biosynthetic pathway into cultivated tomatoes resulted in improved herbivore resistance.</description><subject>Alkyl and Aryl Transferases - genetics</subject><subject>Alkyl and Aryl Transferases - metabolism</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>biochemical pathways</subject><subject>Biological Sciences</subject><subject>Biosynthesis</subject><subject>Biosynthetic Pathways - genetics</subject><subject>breeding</subject><subject>Breeding - methods</subject><subject>Cloning, Molecular</subject><subject>Eggs</subject><subject>Feeding Behavior - physiology</subject><subject>fruit quality</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>greenhouses</subject><subject>Hemiptera - physiology</subject><subject>Herbivores</subject><subject>Herbivory - immunology</subject><subject>Lycopersicon esculentum - genetics</subject><subject>Lycopersicon esculentum - immunology</subject><subject>Lycopersicon esculentum - parasitology</subject><subject>Metabolic Engineering - methods</subject><subject>Mites</subject><subject>Monoterpenes</subject><subject>pests</subject><subject>Plants</subject><subject>Plastids</subject><subject>Polyisoprenyl Phosphates</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Sesquiterpenes</subject><subject>Sesquiterpenes - immunology</subject><subject>Sesquiterpenes - metabolism</subject><subject>sesquiterpenoids</subject><subject>Spiders</subject><subject>Terpenes</subject><subject>Tetranychidae - physiology</subject><subject>Tomatoes</subject><subject>toxicity</subject><subject>Transgenic plants</subject><subject>Trichomes</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAURSMEokNhzQqwxIbNtM92nNibSqjio1IlFtC15TgvHY-SOLWdqebf42iGKbCxJfvco_d0i-IthQsKNb-cRhMvKANZi4qCelas8knXVangebECYPValqw8K17FuAUAJSS8LM4Yp5WquFoV8WaYgt9hSzYYGrfzAUnA6GIyo0XiRmLnPrmdSRlJfjDJk0eXNiRtkESMD7NLGCYckTTOx_2Y35OzZDJp82j2pAt-ICZH-jZ7e5NV-Lp40Zk-4pvjfV7cff3y6_r7-vbHt5vrz7drK5hIa7QIAmXT8LZmrGTQSSVEKaUBYW0rZcuEZF3bNZaaum6wsZVsuJS2ayVFy8-Lq4N3mpsBW4tjCqbXU3CDCXvtjdP__oxuo-_9TnPBuKzKLPh0FAT_MGNMenDRYt-bEf0cNZXAQTFVVRn9-B-69XMY83qasmzLY3GVqcsDZYOPMWB3GoaCXgrVS6H6qdCceP_3Dif-T4MZIEdgST7plC6VZkDZssa7A7KNyYcTU1LJoayX2T8c_jvjtbkPLuq7nzlaAVAOAkr-G_x4vbA</recordid><startdate>20121204</startdate><enddate>20121204</enddate><creator>Bleeker, Petra M</creator><creator>Mirabella, Rossana</creator><creator>Diergaarde, Paul J</creator><creator>VanDoorn, Arjen</creator><creator>Tissier, Alain</creator><creator>Kant, Merijn R</creator><creator>Prins, Marcel</creator><creator>de Vos, Martin</creator><creator>Haring, Michel A</creator><creator>Schuurink, Robert C</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20121204</creationdate><title>Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative</title><author>Bleeker, Petra M ; 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The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with the aim to obtain herbivore resistance. 7-Epizingiberene is a specific sesquiterpene with toxic and repellent properties that is produced and stored in glandular trichomes. We identified 7-epizingiberene synthase (ShZIS) that belongs to a new class of sesquiterpene synthases, exclusively using Z-Z- farnesyl-diphosphate (zFPP) in plastids, probably arisen through neo-functionalization of a common ancestor. Expression of the ShZIS and zFPP synthases in the glandular trichomes of cultivated tomato resulted in the production of 7-epizingiberene. These tomatoes gained resistance to several herbivores that are pests of tomato. Hence, introduction of this sesquiterpene biosynthetic pathway into cultivated tomatoes resulted in improved herbivore resistance.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>23169639</pmid><doi>10.1073/pnas.1208756109</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alkyl and Aryl Transferases - genetics Alkyl and Aryl Transferases - metabolism Analysis of Variance Animals biochemical pathways Biological Sciences Biosynthesis Biosynthetic Pathways - genetics breeding Breeding - methods Cloning, Molecular Eggs Feeding Behavior - physiology fruit quality Gas Chromatography-Mass Spectrometry greenhouses Hemiptera - physiology Herbivores Herbivory - immunology Lycopersicon esculentum - genetics Lycopersicon esculentum - immunology Lycopersicon esculentum - parasitology Metabolic Engineering - methods Mites Monoterpenes pests Plants Plastids Polyisoprenyl Phosphates Real-Time Polymerase Chain Reaction Sesquiterpenes Sesquiterpenes - immunology Sesquiterpenes - metabolism sesquiterpenoids Spiders Terpenes Tetranychidae - physiology Tomatoes toxicity Transgenic plants Trichomes |
| title | Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative |
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