Factors underlying variable DNA methylation in a human community cohort

Epigenetics is emerging as an attractive mechanism to explain the persistent genomic embedding of early-life experiences. Tightly linked to chromatin, which packages DNA into chromosomes, epigenetic marks primarily serve to regulate the activity of genes. DNA methylation is the most accessible and c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-10, Vol.109 (Supplement 2), p.17253-17260
Hauptverfasser:	Lam, Lucia L., Emberly, Eldon, Fraser, Hunter B., Neumann, Sarah M., Chen, Edith, Miller, Gregory E., Kobor, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergartners Sackler Blood Chromatin Chromosomes Cohort Studies COLLOQUIUM PAPERS Correlations cortisol DNA DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetics Female Gene Expression genes Genetic loci Genetic variation Genetics, Population human communities Humans inflammation Leukocytes Leukocytes - metabolism Life Change Events Male Methylation Middle Aged mononuclear leukocytes nationalities and ethnic groups P values Poverty Principal Component Analysis promoter regions Promoter Regions, Genetic psychosocial factors Social Class Socioeconomic factors socioeconomic status Stress, Psychological Toll-like receptors Young Adult
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