Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing

Ribonuclease P (RNase P) catalyzes the maturation of the 5' end of tRNA precursors. Typically these enzymes are ribonucleoproteins with a conserved RNA component responsible for catalysis. However, protein-only RNase P (PRORP) enzymes process precursor tRNAs in human mitochondria and in all tRN...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-10, Vol.109 (40), p.16149-16154
Hauptverfasser:	Howard, Michael J., Lim, Wan Hsin, Fierke, Carol A., Koutmos, Markos
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Arabidopsis - enzymology Arabidopsis thaliana aspartic acid Biochemistry Biological Sciences Catalysis catalysts catalytic activity crystal structure Crystallography, X-Ray Enzymes eukaryotic cells evolution Evolution, Molecular Humans Metal ions Mitochondria Mitochondria - enzymology Mitochondria - physiology mitochondrial genome Models, Molecular prebiotics Protein Structure, Tertiary Proteins Ribonuclease P - chemistry Ribonuclease P - metabolism ribonucleases ribonucleoproteins RNA RNA Precursors - metabolism RNA Processing, Post-Transcriptional - physiology Transfer RNA yeasts Zinc
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