Human blood metabolite timetable indicates internal body time

A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-09, Vol.109 (37), p.15036-15041
Hauptverfasser:	Kasukawa, Takeya, Sugimoto, Masahiro, Hida, Akiko, Minami, Yoichi, Mori, Masayo, Honma, Sato, Honma, Ken-ichi, Mishima, Kazuo, Soga, Tomoyoshi, Ueda, Hiroki R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Clocks - physiology Biological Sciences Blood Blood - metabolism Blood plasma Chromatography, Liquid Chronotherapy - methods Circadian rhythm drugs Eating Food intake Humans Male Mass Spectrometry Mass spectroscopy Medication administration medicine Metabolic diseases Metabolites Metabolomics Metabolomics - methods mice Photoperiod Precision Medicine - methods Rodents Sleep Temperature Time Factors Toxicity University administration Young Adult
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