Human blood metabolite timetable indicates internal body time
A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2012-09, Vol.109 (37), p.15036-15041 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 109 |
| creator | Kasukawa, Takeya Sugimoto, Masahiro Hida, Akiko Minami, Yoichi Mori, Masayo Honma, Sato Honma, Ken-ichi Mishima, Kazuo Soga, Tomoyoshi Ueda, Hiroki R |
| description | A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. Our minimally invasive, molecular-timetable method with human blood enables highly optimized and personalized medicine. |
| doi_str_mv | 10.1073/pnas.1207768109 |
| format | Article |
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Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. 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Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. 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| subjects | Biological Clocks - physiology Biological Sciences Blood Blood - metabolism Blood plasma Chromatography, Liquid Chronotherapy - methods Circadian rhythm drugs Eating Food intake Humans Male Mass Spectrometry Mass spectroscopy Medication administration medicine Metabolic diseases Metabolites Metabolomics Metabolomics - methods mice Photoperiod Precision Medicine - methods Rodents Sleep Temperature Time Factors Toxicity University administration Young Adult |
| title | Human blood metabolite timetable indicates internal body time |
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