BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation

Expression of functional breast cancer susceptibility gene 1 (BRCA1) in human breast and ovarian cancers is associated with resistance to platinum-based chemotherapeutics and poly(ADP ribose) polymerase (PARP) inhibitors. BRCA1 is a nuclear tumor suppressor that is critical for resolving double-stra...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-08, Vol.109 (34), p.13650-13655
Hauptverfasser:	Stecklein, Shane R, Kumaraswamy, Easwari, Behbod, Fariba, Wang, Wenjia, Chaguturu, Vamsee, Harlan-Williams, Lisa M, Jensen, Roy A
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine diphosphate anemia animal ovaries Antineoplastic Agents - pharmacology Benzoquinones - pharmacology Biological Sciences BRCA1 Protein - genetics BRCA1 Protein - physiology Breast cancer breast neoplasms Cancer Cell cycle Cell Division Cell growth Cell Line, Tumor Cell lines Cells Cross-Linking Reagents - pharmacology crosslinking DNA DNA Breaks, Double-Stranded DNA damage DNA Repair Drug Design Drug Screening Assays, Antitumor drug therapy G2 Phase genes Genetic mutation Heat shock proteins heat-shock protein 90 HeLa Cells Homologous Recombination HSP90 Heat-Shock Proteins - metabolism Humans ionization Lactams, Macrocyclic - pharmacology ovarian neoplasms prognosis ribose tumor suppressor proteins Tumors ubiquitination
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