Receptor and Gβ γ Isoform-Specific Interactions with G Protein-Coupled Receptor Kinases

The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate and desensitize agonist-occupied GPCRs. GRK2-mediated receptor phosphorylation is preceded by the agonist-dependent membrane association of this enzyme. Previous in vitro studies with purified proteins have suggested that this transl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-03, Vol.94 (6), p.2180-2185
Hauptverfasser:	Daaka, Yehia, Pitcher, Julie A., Richardson, Mark, Stoffel, Robert H., Robishaw, Janet D., Lefkowitz, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Antibodies Cell membranes COS cells Phosphorylation Protein isoforms Proteins Receptors Thrombin receptors Ungulates
Online-Zugang:	Volltext
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