Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells through up-regulating glutaminase (GLS). Glutamine is converted to glutamate by GLS, entering the tricarboxylic acid cycle as an important energy...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-06, Vol.109 (23), p.8983-8988
Hauptverfasser:	Liu, Wei, Le, Anne, Hancock, Chad, Lane, Andrew N., Dang, Chi V., Fan, Teresa W.-M., Phang, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological Sciences Biosynthesis Blotting, Western Cancer Carbon Isotopes - metabolism Catabolism Cell growth Cell Line, Tumor Cellular metabolism Chromatin Immunoprecipitation delta-1-Pyrroline-5-Carboxylate Reductase DNA-Binding Proteins - metabolism Energy metabolism Gas Chromatography-Mass Spectrometry Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Enzymologic - physiology Gene Knockdown Techniques Glutamine - metabolism Humans Metabolism MicroRNAs - metabolism Nitrogen Isotopes - metabolism Nuclear Magnetic Resonance, Biomolecular Oxidation-Reduction Proline - metabolism Proline Oxidase - metabolism Prostate cancer Pyrroline Carboxylate Reductases - metabolism Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Small interfering RNA T lymphocytes Transcription Factors - metabolism Tumors
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