Genetic switchboard for synthetic biology applications

A key next step in synthetic biology is to combine simple circuits into higher-order systems. In this work, we expanded our synthetic riboregulation platform into a genetic switchboard that independently controls the expression of multiple genes in parallel. First, we designed and characterized ribo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (15), p.5850-5855
Hauptverfasser:	Callura, Jarred M, Cantor, Charles R, Collins, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Sciences Biotechnology Carbon Cells Cellular metabolism Circuits DNA damage E coli Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Gene expression regulation Genes Genetic Engineering Iron Magnesium Messenger RNA metabolic flux Metabolism metabolome Molecular Sequence Data mRNA Mutation - genetics pentose phosphate cycle Pentose phosphate pathway pentoses Protein metabolism quorum sensing RNA Sensors Starvation synthetic biology Synthetic Biology - methods
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