T-Bet-Dependent Expression of Osteopontin Contributes to T Cell Polarization

The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-11, Vol.102 (47), p.17101-17106
Hauptverfasser:	Shinohara, Mari L., Jansson, Marianne, Hwang, Eun Sook, Miriam B. F. Werneck, Glimcher, Laurie H., Cantor, Harvey
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological Sciences CD8-Positive T-Lymphocytes - classification CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - metabolism Cell culture techniques Cell Differentiation - genetics Cells Cells, Cultured Cultured cells Cytokines Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - metabolism Female Gene expression Gene Expression Regulation - genetics Genetic vectors Glycoproteins Immunology Lymphocyte Activation - genetics Macrophages Male Messenger RNA Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Molecular Sequence Data Osteopontin Sialoglycoproteins - biosynthesis Sialoglycoproteins - deficiency Sialoglycoproteins - genetics Sialoglycoproteins - physiology Signal transduction T cell antigen receptors T lymphocytes T-Box Domain Proteins T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - metabolism Th1 Cells - cytology Th1 Cells - metabolism Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology
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