$Myosin Motor Myo1C and Its Receptor$NEMO/IKK-\gamma$Promote$TNF-\alpha-Induced$ $Serine^{307}$Phosphorylation of IRS-1$

Myosin Motor Myo1C and Its Receptor$NEMO/IKK-\gamma$Promote$TNF-\alpha-Induced$ $Serine^{307}$Phosphorylation of IRS-1

Tumor necrosis$factor-\alpha$($TNF-\alpha$) signaling through the Iκ B kinase (IKK) complex attenuates insulin action via the phosphorylation of insulin receptor substrate 1 (IRS-1) at$Ser^{307}$. However, the precise molecular mechanism by which the IKK complex phosphorylates IRS-1 is unknown. In t...

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Veröffentlicht in:	The Journal of cell biology 2006-06, Vol.173 (5), p.665-671
Hauptverfasser:	Yoshitaka Nakamori, Masahiro Emoto, Naofumi Fukuda, Taguchi, Akihiko, Shigeru Okuya, Michiko Tajiri, Miyagishi, Makoto, Taira, Kazunari, Wada, Yoshinao, Tanizawa, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Adipocytes Antibodies Freight Insulin Insulin resistance Molecules Phosphorylation Receptors Ruffles
Online-Zugang:	Volltext
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