ApoE-Directed Therapeutics Rapidly Clear ß-Amyloid and Reverse Deficits in AD Mouse Models

Alzheimer's disease (AD) is associated with impaired clearance of ß-amyloid (Aß) from the brain, a process normally facilitated by apolipoprotein E (apoE). ApoE expression is transcriptionally induced through the action of the nuclear receptors peroxisome proliferator-activated receptor gamma a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2012-03, Vol.335 (6075), p.1503-1506
Hauptverfasser:	Cramer, Paige E., Cirrito, John R., Wesson, Daniel W., Lee, C. Y. Daniel, Karlo, J. Colleen, Zinn, Adriana E., Casali, Brad T., Restivo, Jessica L., Goebel, Whitney D., James, Michael J., Brunden, Kurt R., Wilson, Donald A., Landreth, Gary E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimers disease Behavioral neuroscience Hippocampus Mice Microglia Neural conduction Odors Receptors T tests Vehicles
Online-Zugang:	Volltext
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