Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells

The boronic acid dipeptide bortezomib inhibits the chymotrypsin-like activity of the 26S proteasome and shows significant therapeutic efficacy in multiple myeloma. However, recent studies suggest that bortezomib may have more complex mechanisms of action in treating cancer. We report here that the e...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (7), p.2521-2526
Hauptverfasser:	Fang, Hai-Tong, Zhang, Bo, Pan, Xiao-Fen, Gao, Li, Zhen, Tao, Zhao, Hong-Xia, Ma, Liang, Xie, Jun, Liu, Zi, Yu, Xian-Jun, Cheng, Xin, Feng, Ting-Ting, Zhang, Feng-Xiang, Yang, Yong, Hu, Zhong-Guo, Sheng, Guo-Qing, Chen, Yong-Long, Chen, Sai-Juan, Chen, Zhu, Zhou, Guang-Biao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Apaf-1 protein Apoptosis Biological Sciences Boronic Acids - pharmacology Bortezomib c-Kit protein Cancer Caspase-3 Cells Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 COS cells Data processing Endocytosis Fusion protein Heat shock proteins Humans Internalization Leukemia Leukemia - genetics Leukemia - pathology Lysosomes Mice Multiple myeloma Myeloid leukemia myeloma Phosphorylation Plasmids Protease inhibitors proteasome endopeptidase complex proteasomes Protein Binding Protein-tyrosine kinase Protein-tyrosine kinase receptors Proteinase Proteins Proto-Oncogene Proteins c-kit - metabolism Pyrazines - pharmacology Receptors Stem cells Transcription factors Translocation, Genetic Tumor cells Tumors tyrosine
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