Variants of the Mannose-Binding Lectin Gene in the Benin Population: Heterozygosity for the p. G57E Allele May Confer a Selective Advantage

Human mannose-binding lectin (MBL) plays an important role in innate immunity. MBL deficiency is associated with mutations in the promoter region and in exon 1 of the MBL2 gene. Such deficiency has been correlated with elevated incidence of infections in infancy and in immunocompromised adults. We d...

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Veröffentlicht in:	Human biology 2009-10, Vol.81 (5/6), p.899-909
Hauptverfasser:	DOSSOU-YOVO, OMER PLACIDE, LAPOUMEROULIE, CLAUDINE, HAUCHECORNE, MICHELLE, ZACCARIA, ISABELLE, DUCROCQ, ROLANDE, KRISHNAMOORTHY, RAJAGOPAL, RAHIMY, MOHAMED CHÉRIF, ELION, JACQUES
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Children Evolution Exons Genotypes Haplotypes Heterozygotes Infections Lectins Meningeal tuberculosis
Online-Zugang:	Volltext
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