Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs processing involves the Fanconi anemia (FA) pathway and homologous recombination. Stalled replication forks activate the eight-subunit FA core complex, which ubiquitylates FAN...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (16), p.6492-6496
Hauptverfasser:	Yamamoto, Kimiyo N, Kobayashi, Shunsuke, Tsuda, Masataka, Kurumizaka, Hitoshi, Takata, Minoru, Kono, Koichi, Jiricny, Josef, Takeda, Shunichi, Hirota, Kouji
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Apoptosis Binding sites Biological Sciences birds Cell cycle cell death Cell Death - drug effects Cell Death - genetics Cell growth Cell Line cell proliferation Cell Proliferation - drug effects Chickens chromatids Chromatids - genetics Chromatids - metabolism Chromosome aberrations Chromosome Aberrations - drug effects Chromosomes Cross-Linking Reagents - pharmacology crosslinking cytotoxicity DNA DNA damage DNA Damage - drug effects DNA Damage - physiology DNA repair DNA Repair - drug effects DNA Repair - physiology Endonucleases - genetics Endonucleases - metabolism Enzymes Eukaryotes eukaryotic cells Fanconi anemia Fanconi Anemia Complementation Group D2 Protein - genetics Fanconi Anemia Complementation Group D2 Protein - metabolism genes Genetic vectors Homologous recombination Multiprotein Complexes - genetics Multiprotein Complexes - metabolism nucleases Proteins Recombinases - genetics Recombinases - metabolism Recombination, Genetic - drug effects Recombination, Genetic - physiology Ubiquitination - drug effects Ubiquitination - physiology zinc finger motif Zinc Fingers
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