T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

The Wnt/Î²-catenin pathway plays multiple and diverse roles in development by regulating gene expression via T-cell factor/Lymphoid enhancer-binding factor (Tcf/Lef) DNA binding factors. Misregulation of this pathway is thought to initiate colon adenoma formation. It is controversial whether Tcf4 (T...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (12), p.4914-4919
Hauptverfasser:	Angus-Hill, Melinda L, Elbert, Kathryn M, Hidalgo, Julio, Capecchi, Mario R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Animal models Animals beta Catenin - genetics beta Catenin - metabolism Binding sites Biological Sciences Carcinogenesis catenin Cell growth Cell lines Cell Proliferation Colon Colon - metabolism Colonic neoplasms Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colorectal cancer colorectal neoplasms Crypts Development DNA early development Embryos Epithelial cells Epithelium Gene expression haploinsufficiency Humans in vivo studies Intestine Intestines LEF protein Mice Mice, Transgenic Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Oncogenes Proteins Small intestine Stem cells Studies T-lymphocytes Tcf protein Transcription Factor 7-Like 2 Protein - genetics Transcription Factor 7-Like 2 Protein - metabolism Transcription factors Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumorigenesis Tumors Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism
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